The Frank Porter Graham Child Development Center (FPG) is a multidisciplinary research and development center devoted to the study of psychological, educational, biomedical, and social aspects of mental retardation and related problems of development. The basic research theme of the FPG Center over the past decade has focused on the complex interaction of medical, psychological and social factors that influence competent development during early childhood and through the elementary school years. In addition to a multi-disciplinary perspective, the research strategy at the FPG Center emphasizes the longitudinal study of multiple variables in a variety of ecologies that impact early development. In addition to the basic research program, the FPG Center has embarked on an expanded program of development, demonstration, training, service and policy analysis. Thus, they have been concerned with (1) the organization and synthesis of knowledge to meet specific needs of children and their families, (2) the design and demonstration of new delivery systems to provide technical assistance, and (3) the preparation of personnel to meet the variety of roles needed to support programs for the mentally retarded and related developmental problems. The Biological Sciences Research Center (BSRC) continues to conduct research related to mental retardation and related aspects of human development simultaneously at three levels. There is fundamental laboratory research on the development of the central nervous system. There is further fundamental research upon internal and external factors which may alter or impede this development. And there is highly applied research dealing with early detection and therapeutic intervention in children at risk for retarded development or aberrant behavior. BSRC scientists continue to be very productive in publications and successful in the acquisition of new grant funds. Additionally, the BSRC is beginning a formal program of cross-disciplinary research training for postdoctoral and advanced pre-doctoral students.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
Project #
Application #
Study Section
Mental Retardation Research and Training Committee (HDMR)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Overall Medical
Chapel Hill
United States
Zip Code
Jha, Shaili C; Xia, Kai; Schmitt, James Eric et al. (2018) Genetic influences on neonatal cortical thickness and surface area. Hum Brain Mapp 39:4998-5013
Barstein, Jamie; Martin, Gary E; Lee, Michelle et al. (2018) A Duck Wearing Boots?! Pragmatic Language Strategies for Repairing Communication Breakdowns Across Genetically Based Neurodevelopmental Disabilities. J Speech Lang Hear Res 61:1440-1454
Woodbury-Smith, Marc; Paterson, Andrew D; O'Connor, Irene et al. (2018) A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees. J Neurodev Disord 10:20
DuBay, Michaela; Watson, Linda R; Zhang, Wanqing (2018) In Search of Culturally Appropriate Autism Interventions: Perspectives of Latino Caregivers. J Autism Dev Disord 48:1623-1639
Sterling, Audra; Warren, Steven F (2018) Parenting of children with Down syndrome compared to fragile X syndrome. Dev Neurorehabil 21:64-67
Klusek, Jessica; Porter, Anna; Abbeduto, Leonard et al. (2018) Curvilinear Association Between Language Disfluency and FMR1 CGG Repeat Size Across the Normal, Intermediate, and Premutation Range. Front Genet 9:344
Adlof, Suzanne M; Klusek, Jessica; Hoffmann, Anne et al. (2018) Reading in Children With Fragile X Syndrome: Phonological Awareness and Feasibility of Intervention. Am J Intellect Dev Disabil 123:193-211
Mostapha, Mahmoud; Shen, Mark D; Kim, SunHyung et al. (2018) A Novel Framework for the Local Extraction of Extra-Axial Cerebrospinal Fluid from MR Brain Images. Proc SPIE Int Soc Opt Eng 10574:
Swanson, Meghan R; Wolff, Jason J; Shen, Mark D et al. (2018) Development of White Matter Circuitry in Infants With Fragile X Syndrome. JAMA Psychiatry 75:505-513
Swanson, Meghan R; Shen, Mark D; Wolff, Jason J et al. (2018) Naturalistic Language Recordings Reveal ""Hypervocal"" Infants at High Familial Risk for Autism. Child Dev 89:e60-e73

Showing the most recent 10 out of 376 publications