Abstract

The Mass Spectrometry Center is equipped with (1) a VG/Micromass 7070E double focusing mass spectrometer with electron ionization (EI), chemical ionization (CI), and fast atom bombardment (FAB) ionization modes that may be operated in either the positive-ion or the negative-ion mode, equipped with a continuous-flow FAB probe, (2) a VG/Micromass gas isotope ratio mass spectrometer, (3,4) two Hewlett-Packard MSD capillary gas chromatograph-mass spectrometer systems with low resolution, electron ionization, positive-ion mode GC/MS operation only, and (5) a Hewlett-Packard 5989A MS engine capable of electron ionization and chemical ionization, equipped with an HP 5890 gas chromatograph and auto injection. The laboratory also performs organic synthesis of stable-isotope-labeled and other specialty chemicals. About 10 percent of the activity of the MS Center serves this MRRD program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD004024-34
Application #
6641488
Study Section
Project Start
2002-08-01
Project End
2003-07-31
Budget Start
Budget End
Support Year
34
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Yerys, Benjamin E; Wolff, Brian C; Moody, Eric et al. (2012) Brief Report: impaired Flexible Item Selection Task (FIST) in school-age children with autism spectrum disorders. J Autism Dev Disord 42:2013-20
Estrada-Bernal, Adriana; Sanford, Staci D; Sosa, Lucas J et al. (2012) Functional complexity of the axonal growth cone: a proteomic analysis. PLoS One 7:e31858
Kern, D S; Maclean, K N; Jiang, H et al. (2011) Neural stem cells reduce hippocampal tau and reelin accumulation in aged Ts65Dn Down syndrome mice. Cell Transplant 20:371-9
Swanson, Michael A; Kathirvelu, Velavan; Majtan, Tomas et al. (2011) Electron transfer flavoprotein domain II orientation monitored using double electron-electron resonance between an enzymatically reduced, native FAD cofactor, and spin labels. Protein Sci 20:610-20
Moon, Jisook; Chen, May; Gandhy, Shruti U et al. (2010) Perinatal choline supplementation improves cognitive functioning and emotion regulation in the Ts65Dn mouse model of Down syndrome. Behav Neurosci 124:346-61
Maclean, Kenneth N; Sikora, Jakub; Kozich, Viktor et al. (2010) A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment. Mol Genet Metab 101:153-62
Moat, Stuart; Carling, Rachel; Nix, Authur et al. (2010) Multicentre age-related reference intervals for cerebrospinal fluid serine concentrations: implications for the diagnosis and follow-up of serine biosynthesis disorders. Mol Genet Metab 101:149-52
Nielsen, Darci M; Evans, Jeffrey J; Derber, William J et al. (2009) Mouse model of fragile X syndrome: behavioral and hormonal response to stressors. Behav Neurosci 123:677-86
Swanson, Michael A; Kathirvelu, Velavan; Majtan, Tomas et al. (2009) DEER distance measurement between a spin label and a native FAD semiquinone in electron transfer flavoprotein. J Am Chem Soc 131:15978-9
Stoecker, B J; Abebe, Y; Hubbs-Tait, L et al. (2009) Zinc status and cognitive function of pregnant women in Southern Ethiopia. Eur J Clin Nutr 63:916-8

Showing the most recent 10 out of 27 publications