Abstract

The Radioimmunoassay (RIA) Core provides valuable radioimmunoassay services to HPC associates conducting research on basic biology, and on population-based reproductive function and behaviors. In addition to providing assay services for a large scale epidemiologic studies, the Core provides assay services to HPC scientists performing basic research in reproduction. For example, Core facilities were made available to perform steroid and prostaglandin assays on perfusate samples taken during experiments designed to elucidate biologic processes involved in ovulation. More recently, assay services have been provided for basic research studies investigating the interaction between the environment and reproductive behaviors. The following standard peptide, steroid and prostaglandin assays are available within the RIA Core laboratory: 1. Rat Pituitary Peptide Assay LH, FSH, PRL, TSH, GH 2. Human Pituitary Peptide Assays LH, FSH, PRL, TSH 3. Steroid Assays progesterone, estradiol, 17-OH progesterone, testosterone 4. Urinary Steroid Glucuronide Assays 5. Prostaglandin assays PGE2 and PGF2(alpha) The following Specialized Assays are also available: 1. Norethindrone and ethinyl estradiol 2. CA 125 3. Urinary hCG

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
3P30HD006268-28S1
Application #
6618229
Study Section
Project Start
2001-07-01
Project End
2003-06-30
Budget Start
Budget End
Support Year
28
Fiscal Year
2002
Total Cost
$191,743
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Becker, Stan; Hossain, Mian B; Thomson, Elizabeth (2006) Disagreement in spousal reports of current contraceptive use in sub-Saharan Africa. J Biosoc Sci 38:779-96
Misra, Dawn P; Astone, Nan; Lynch, Courtney D (2005) Maternal smoking and birth weight: interaction with parity and mother's own in utero exposure to smoking. Epidemiology 16:288-93
Choi, Yoonjoung; Bishai, David; Hill, Kenneth (2005) Socioeconomic differentials in supplementation of vitamin A: evidence from the Philippines. J Health Popul Nutr 23:156-64
Kagaayi, Joseph; Dreyfuss, Michele L; Kigozi, Godfrey et al. (2005) Maternal self-medication and provision of nevirapine to newborns by women in Rakai, Uganda. J Acquir Immune Defic Syndr 39:121-4
Beenhakker, Britta; Becker, Stan; Hires, Stephanie et al. (2004) Are partners available for post-abortion contraceptive counseling? A pilot study in a Baltimore City clinic. Contraception 69:419-23
Hanna, William F; Kerr, Candace L; Shaper, Joel H et al. (2004) Lewis X-containing neoglycoproteins mimic the intrinsic ability of zona pellucida glycoprotein ZP3 to induce the acrosome reaction in capacitated mouse sperm. Biol Reprod 71:778-89
Hinson, Ella R; Shone, Scott M; Zink, M Christine et al. (2004) Wounding: the primary mode of Seoul virus transmission among male Norway rats. Am J Trop Med Hyg 70:310-7
Wisniewski, Amy B; Klein, Sabra L; Lakshmanan, Yegappen et al. (2003) Exposure to genistein during gestation and lactation demasculinizes the reproductive system in rats. J Urol 169:1582-6
Charron, Martin; DeCerbo, Joshua N; Wright, William W (2003) A GC-box within the proximal promoter region of the rat cathepsin L gene activates transcription in Sertoli cells of sexually mature rats. Biol Reprod 68:1649-56
Charron, Martin; Folmer, Janet S; Wright, William W (2003) A 3-kilobase region derived from the rat cathepsin L gene directs in vivo expression of a reporter gene in sertoli cells in a manner comparable to that of the endogenous gene. Biol Reprod 68:1641-8

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