Abstract

The broad and long-term objectives of the Center are to elucidate the endocrine and neuroendocrine control systems which govern the reproductive processes in a representative primate, the rhesus monkey. The Center comprises the following project and research resources (cores): The Properties of the Pituitary Glycoprotein Hormones; The Neuroendocrine Control of Reproduction in the Male Rhesus Monkey; Cellular Basis of Control of Gonadotropin Hormone Section by Gonadal Steroids; Control of Folliculogenesis in the Rhesus Monkey; Gonadal Hormone Metabolism in the Rhesus Monkey. The cores are: The Primate Research Laboratory (Primate Core), A Steroid Hormone Radioimmunoassay Laboratory, A Polypeptide Hormone Radioimmunoassay Laboratory, and an Administrative Core. The Primate Core houses 280 rhesus monkeys and provides all attendant facilities for their acquisition and care. The Center is also the focus of a major postdoctoral training program in primate reproduction.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD008610-14
Application #
3102881
Study Section
Population Research and Training Committee (HDPR)
Project Start
1979-09-29
Project End
1990-11-30
Budget Start
1987-12-01
Budget End
1988-11-30
Support Year
14
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Pittsburgh
Department
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213

  Publications

Kalil, Bruna; Ramaswamy, Suresh; Plant, Tony M (2016) The Distribution of Substance P and Kisspeptin in the Mediobasal Hypothalamus of the Male Rhesus Monkey and a Comparison of Intravenous Administration of These Peptides to Release GnRH as Reflected by LH Secretion. Neuroendocrinology 103:711-23
Plant, Tony M (2015) Neuroendocrine control of the onset of puberty. Front Neuroendocrinol 38:73-88
Watts, Alan G (2015) 60 YEARS OF NEUROENDOCRINOLOGY: The structure of the neuroendocrine hypothalamus: the neuroanatomical legacy of Geoffrey Harris. J Endocrinol 226:T25-39
Plant, Tony M (2015) 60 YEARS OF NEUROENDOCRINOLOGY: The hypothalamo-pituitary-gonadal axis. J Endocrinol 226:T41-54
Gassei, Kathrin; Orwig, Kyle E (2013) SALL4 expression in gonocytes and spermatogonial clones of postnatal mouse testes. PLoS One 8:e53976
Majumdar, Subeer S; Sarda, Kanchan; Bhattacharya, Indrashis et al. (2012) Insufficient androgen and FSH signaling may be responsible for the azoospermia of the infantile primate testes despite exposure to an adult-like hormonal milieu. Hum Reprod 27:2515-25
Ochalski, Melanie E; Shuttleworth, Jennifer J; Chu, Tianjiao et al. (2011) Thalidomide treatment attenuates chemotherapy-induced gonadal toxicity. Fertil Steril 95:819-22
Mann, David R; Plant, Tony M (2010) The role and potential sites of action of thyroid hormone in timing the onset of puberty in male primates. Brain Res 1364:175-85
Phillips, Bart T; Gassei, Kathrin; Orwig, Kyle E (2010) Spermatogonial stem cell regulation and spermatogenesis. Philos Trans R Soc Lond B Biol Sci 365:1663-78
Grimes, Michael A; Cameron, Judy L; Fernstrom, John D (2009) Cerebrospinal fluid concentrations of large neutral and basic amino acids in Macaca mulatta: diurnal variations and responses to chronic changes in dietary protein intake. Metabolism 58:129-40

Showing the most recent 10 out of 23 publications