Abstract

This is a competitive renewal application for a Population Center Grant (P30) from the OREGON REGIONAL PRIMATE RESEARCH CENTER (ORPRC) that requests support for core services to facilitate individual research programs with qualified NICHD mission objectives. Core support is requested for radioimmunoassays and bioassays (RIA), morphology (MOR) including electron microscopy and in situ hybridization, cell culture (CC) reagents, unfertilized and fertilized gametes (IVF-EE) including transgenic animals, and for program administration (ADM). The research group comprises at least 21 investigators (PIs) with appropriate funding who utilize multidisciplinary approaches for the study of primate reproduction. Specific areas of active research include: neuroendocrine events influencing the hypophyseal-gonadal axis during peripuberty and in adults; steroid hormone mechanisms in the brain and reproductive tract; endocrine physiology of the menstrual cycle and pregnancy; control of sperm motility; in vivo and in vitro fertilization; genomic processes in opiate peptide expression and in adrenergic receptor function; reproductive photoperiodicity; paracrine factors in neural and reproductive tissues; and neural- ana endocrine changes during aging. The existence of these facilities will enhance collaboration among members of these units and prevent unnecessary duplication of equipment, personnel and technologies.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018185-10
Application #
3102944
Study Section
Special Emphasis Panel (SRC (SP))
Project Start
1984-09-01
Project End
1994-08-31
Budget Start
1993-09-01
Budget End
1994-08-31
Support Year
10
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
Oregon Regional Primate Research Center
Department
Type
DUNS #
City
Beaverton
State
OR
Country
United States
Zip Code
97006

  Publications

Bethea, C L; Reddy, A P (2015) Ovarian steroids regulate gene expression related to DNA repair and neurodegenerative diseases in serotonin neurons of macaques. Mol Psychiatry 20:1565-78
Rivera, H M; Bethea, C L (2012) Ovarian steroids increase spinogenetic proteins in the macaque dorsal raphe. Neuroscience 208:27-40
Dissen, G A; Lomniczi, A; Boudreau, R L et al. (2012) Targeted gene silencing to induce permanent sterility. Reprod Domest Anim 47 Suppl 4:228-32
Tachibana, Masahito; Sparman, Michelle; Ramsey, Cathy et al. (2012) Generation of chimeric rhesus monkeys. Cell 148:285-95
Lee, Hyo-Sang; Ma, Hong; Juanes, Rita Cervera et al. (2012) Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck. Cell Rep 1:506-15
Tachibana, Masahito; Ma, Hong; Sparman, Michelle L et al. (2012) X-chromosome inactivation in monkey embryos and pluripotent stem cells. Dev Biol 371:146-55
Sorwell, Krystina G; Kohama, Steven G; Urbanski, Henryk F (2012) Perimenopausal regulation of steroidogenesis in the nonhuman primate. Neurobiol Aging 33:1487.e1-13
Dorfman, Mauricio D; Kerr, Bredford; Garcia-Rudaz, Cecilia et al. (2011) Neurotrophins acting via TRKB receptors activate the JAGGED1-NOTCH2 cell-cell communication pathway to facilitate early ovarian development. Endocrinology 152:5005-16
Garcia-Rudaz, Cecilia; Dorfman, Mauricio; Nagalla, Srinivasa et al. (2011) Excessive ovarian production of nerve growth factor elicits granulosa cell apoptosis by setting in motion a tumor necrosis factor ?/stathmin-mediated death signaling pathway. Reproduction 142:319-31
Adams Waldorf, K M; Rubens, C E; Gravett, M G (2011) Use of nonhuman primate models to investigate mechanisms of infection-associated preterm birth. BJOG 118:136-44

Showing the most recent 10 out of 96 publications