Abstract

An existing multidepartmental, interdisciplinary program of research projects and core facilities focusing on gonadotropins in reproductive biology has been brought together as a Specialized Population Research Center. The Center involves the efforts of 11 faculty members associated with 7 departments in the University: Anatomy, Internal Medicine, Obstetrics and Gynecology, Oral Biology, Pathology, Pediatrics and Physiology. The approaches involved range from cellular and molecular to physiological and clinical, with extensive integration of the various levels. Animal models include rats, rabbits, sheep, monkeys and human beings. Major research emphasis is on the following problem areas: role of gonadotropins in regulation of ovarian cyclicity; localization, regulation, function and action of gonadotropin releasing hormone; estrogen action in corpora lutea; and molecular and cellular mechanisms and consequences of gonadotropin action in the ovary, inclucing the regulation of follicular development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018258-02
Application #
3102949
Study Section
Population Research and Training Committee (HDPR)
Project Start
1984-03-01
Project End
1989-02-28
Budget Start
1985-03-01
Budget End
1986-02-28
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109

  Publications

Mahoney, Megan M; Rossi, Brooke V; Hagenauer, Megan H et al. (2011) Characterization of the estrous cycle in Octodon degus. Biol Reprod 84:664-71
Tsuneta, Taeko; Loch-Caruso, Rita; Quensen 3rd, John F et al. (2008) Stimulatory effects of a microbially dechlorinated polychlorinated biphenyl (PCB) mixture on rat uterine contraction in vitro. Environ Res 107:185-93
Caruso, Rita Loch; Upham, Brad L; Harris, Craig et al. (2005) Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells. Toxicol Sci 86:417-26
Loch-Caruso, Rita; Upham, Brad L; Harris, Craig et al. (2005) Divergent roles for glutathione in lindane-induced acute and delayed-onset inhibition of rat myometrial gap junctions. Toxicol Sci 85:694-702
Billings, Heather J; Viguie, Catherine; Karsch, Fred J et al. (2002) Temporal requirements of thyroid hormones for seasonal changes in LH secretion. Endocrinology 143:2618-25
Viguie, C; Jansen, H T; Glass, J D et al. (2001) Potential for polysialylated form of neural cell adhesion molecule-mediated neuroplasticity within the gonadotropin-releasing hormone neurosecretory system of the ewe. Endocrinology 142:1317-24
Olson, K K; Anderson, L E; Wiltbank, M C et al. (2001) Actions of prostaglandin F2alpha and prolactin on intercellular adhesion molecule-1 expression and monocyte/macrophage accumulation in the rat corpus luteum. Biol Reprod 64:890-7
Wang, C T; Peters-Golden, M; Loch-Caruso, R (2001) A calcium-independent phospholipase activity insensitive to bromoenol lactone mediates arachidonic acid release by lindane in rat myometrial cells. Life Sci 70:453-70
Krieger, T R; Loch-Caruso, R (2001) Antioxidants prevent gamma-hexachlorocyclohexane-induced inhibition of rat myometrial gap junctions and contractions. Biol Reprod 64:537-47
Bae, J; Mousa, M A; Quensen 3rd, J F et al. (2001) Stimulation of contraction of pregnant rat uterus in vitro by non-dechlorinated and microbially dechlorinated mixtures of polychlorinated biphenyls. Environ Health Perspect 109:275-82

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