Abstract

This program-project requests CORE and implementation support for a broadly based program for the study of mental retardation and related aspects of human development. The scientific base for the program rests upon investigation in three major areas: (a) Genetics and Metabolism; (b) Neuroscience; (c) Behavioral Science; all converging on a fourth area, (d) Clinical Studies of the Human Subject. The methodological and philosophical approaches include the clinical disciplines of pediatrics, neurology, neurosurgery, radiology, psychiatry, psychology, ophthalmology, otology and the basic science disciplines of pathology, physiology, pharmacology and biochemistry. The program is housed in five floors of the Pediatric Sciences Building. The objective of the program is to provide a scientific and clinical base for the better understanding of the factors leading to mental retardation and to apply this information to prevention of the disorder, and management of the mentally handicapped individual.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018655-03
Application #
3102967
Study Section
Mental Retardation Research and Training Committee (HDMR)
Project Start
1983-01-01
Project End
1986-12-31
Budget Start
1985-01-01
Budget End
1985-12-31
Support Year
3
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code

  Publications

Perrin, Eliana M; O'Shea, T Michael; Skinner, Asheley Cockrell et al. (2018) Elevations of inflammatory proteins in neonatal blood are associated with obesity and overweight among 2-year-old children born extremely premature. Pediatr Res 83:1110-1119
Leviton, Alan; Joseph, Robert M; Allred, Elizabeth N et al. (2018) Antenatal and neonatal antecedents of learning limitations in 10-year old children born extremely preterm. Early Hum Dev 118:8-14
Leviton, Alan; Hooper, Stephen R; Hunter, Scott J et al. (2018) Antecedents of Screening Positive for Attention Deficit Hyperactivity Disorder in Ten-Year-Old Children Born Extremely Preterm. Pediatr Neurol 81:25-30
Richmond, Camilla A; Rickner, Hannah; Shah, Manasvi S et al. (2018) JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports 10:17-26
Sieker, Jakob T; Proffen, Benedikt L; Waller, Kimberly A et al. (2018) Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. J Orthop Res :
Waber, Deborah P; Bryce, Cyralene P; Girard, Jonathan M et al. (2018) Parental history of moderate to severe infantile malnutrition is associated with cognitive deficits in their adult offspring. Nutr Neurosci 21:195-201
Leviton, Alan; Dammann, Olaf; Allred, Elizabeth N et al. (2018) Neonatal systemic inflammation and the risk of low scores on measures of reading and mathematics achievement at age 10 years among children born extremely preterm. Int J Dev Neurosci 66:45-53
O'Connell, Amy E; Zhou, Fanny; Shah, Manasvi S et al. (2018) Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet 103:131-137
Hirschberger, Rachel G; Kuban, Karl C K; O'Shea, Thomas M et al. (2018) Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm. Pediatr Neurol 79:45-52
Korzeniewski, Steven J; Allred, Elizabeth N; O'Shea, T Michael et al. (2018) Elevated protein concentrations in newborn blood and the risks of autism spectrum disorder, and of social impairment, at age 10 years among infants born before the 28th week of gestation. Transl Psychiatry 8:115

Showing the most recent 10 out of 1442 publications