Abstract

This program-project requests CORE and implementation support for a broadly based program for the study of mental retardation and related aspects of human development. The scientific base for the program rests upon investigation in three major areas: (a) Genetics and Metabolism; (b) Neuroscience; (c) Behavioral Science; all converging on a fourth area, (d) Clinical Studies of the Human Subject. The methodological and philosophical approaches include the clinical disciplines of pediatrics, neurology, neurosurgery, radiology, psychiatry, psychology, ophthalmology, otology and the basic science disciplines of pathology, physiology, pharmacology and biochemistry. The program is housed in five floors of the Pediatric Sciences Building. The objective of the program is to provide a scientific and clinical base for the better understanding of the factors leading to mental retardation and to apply this information to prevention of the disorder, and management of the mentally handicapped individual.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
2P30HD018655-05
Application #
3102965
Study Section
Mental Retardation Research and Training Committee (HDMR)
Project Start
1983-01-01
Project End
1991-12-31
Budget Start
1987-01-01
Budget End
1987-12-31
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

O'Shea, Thomas M; Joseph, Robert M; Allred, Elizabeth N et al. (2018) Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm. J Perinatol 38:908-916
Liu, Yuanyuan; Latremoliere, Alban; Li, Xinjian et al. (2018) Touch and tactile neuropathic pain sensitivity are set by corticospinal projections. Nature 561:547-550
Chen, Bo; Li, Yi; Yu, Bin et al. (2018) Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations. Cell 174:521-535.e13
Ci, Yanpeng; Li, Xiaoning; Chen, Maorong et al. (2018) SCF?-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation. Protein Cell 9:879-889
Sieker, Jakob T; Proffen, Benedikt L; Waller, Kimberly A et al. (2018) Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis. J Orthop Res 36:318-329
Leviton, Alan; Allred, Elizabeth N; Joseph, Robert M et al. (2018) Behavioural dysfunctions of 10-year-old children born extremely preterm associated with corticotropin-releasing hormone expression in the placenta. Acta Paediatr 107:1932-1936
Sieberg, Christine B; Taras, Caitlin; Gomaa, Aya et al. (2018) Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients. Pain Rep 3:e651
Markowitz, Jeffrey E; Gillis, Winthrop F; Beron, Celia C et al. (2018) The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection. Cell 174:44-58.e17
Masuyer, Geoffrey; Zhang, Sicai; Barkho, Sulyman et al. (2018) Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity. Sci Rep 8:4518
Cakir, Bertan; Liegl, Raffael; Hellgren, Gunnel et al. (2018) Thrombocytopenia is associated with severe retinopathy of prematurity. JCI Insight 3:

Showing the most recent 10 out of 1442 publications