Abstract

This program-project requests CORE and implementation support for a broadly based program for the study of mental retardation and related aspects of human development. The scientific base for the program rests upon investigation in three major areas: (a) Genetics and Metabolism; (b) Neuroscience; (c) Behavioral Science; all converging on a fourth area, (d) Clinical Studies of the Human Subject. The methodological and philosophical approaches include the clinical disciplines of pediatrics, neurology, neurosurgery, radiology, psychiatry, psychology, ophthalmology, otology and the basic science disciplines of pathology, physiology, pharmacology and biochemistry. The program is housed in five floors of the Pediatric Sciences Building. The objective of the program is to provide a scientific and clinical base for the better understanding of the factors leading to mental retardation and to apply this information to prevention of the disorder, and management of the mentally handicapped individual.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD018655-07
Application #
3102970
Study Section
Mental Retardation Research and Training Committee (HDMR)
Project Start
1983-01-01
Project End
1991-12-31
Budget Start
1989-01-01
Budget End
1989-12-31
Support Year
7
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Moore, Anna R; Richards, Sarah E; Kenny, Katelyn et al. (2018) Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits. Elife 7:
Winawer, Melodie R; Griffin, Nicole G; Samanamud, Jorge et al. (2018) Somatic SLC35A2 variants in the brain are associated with intractable neocortical epilepsy. Ann Neurol 83:1133-1146
Bourassa, Daisy; Elitt, Christopher M; McCallum, Adam M et al. (2018) Chromis-1, a Ratiometric Fluorescent Probe Optimized for Two-Photon Microscopy Reveals Dynamic Changes in Labile Zn(II) in Differentiating Oligodendrocytes. ACS Sens 3:458-467
Leviton, Alan; Joseph, Robert M; Allred, Elizabeth N et al. (2018) Antenatal and Neonatal Antecedents of Executive Dysfunctions in Extremely Preterm Children. J Child Neurol 33:198-208
Hong, Y Kate; Burr, Eliza F; Sanes, Joshua R et al. (2018) Heterogeneity of retinogeniculate axon arbors. Eur J Neurosci :
Chen, Peng; Tao, Liang; Wang, Tianyu et al. (2018) Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B. Science 360:664-669
Anderson, Matthew P (2018) DEPDC5 takes a second hit in familial focal epilepsy. J Clin Invest 128:2194-2196
Fischer, Kathryn D; Houston, Alex C W; Desai, Rajeev I et al. (2018) Behavioral phenotyping and dopamine dynamics in mice with conditional deletion of the glutamate transporter GLT-1 in neurons: resistance to the acute locomotor effects of amphetamine. Psychopharmacology (Berl) 235:1371-1387
Lehrman, Emily K; Wilton, Daniel K; Litvina, Elizabeth Y et al. (2018) CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development. Neuron 100:120-134.e6
Burnett, Alice C; Anderson, Peter J; Joseph, Robert M et al. (2018) Hand Preference and Cognitive, Motor, and Behavioral Functioning in 10-Year-Old Extremely Preterm Children. J Pediatr 195:279-282.e3

Showing the most recent 10 out of 1442 publications