Abstract

The Genetics Core provides laboratory support involving specialized genetic methodologies to Center investigators. A variety of services are proposed. Tissues cultures support involves the establishment, propagation, and cryogenic storage of lymphoblastoid and fibroblast cell lines. Cytogenetic support, through the Kennedy Krieger clinical cytogenetic laboratory, provides routine and specialized chromosome analysis. Also through this laboratory is the services of molecular cytogenetics,involving in situ hybridization for map assignment or deletion/rearrangement studies. Biochemical services provide a standard set of comprehensive biochemical analyses, such as amino acid and organic acid studies. Finally molecular genetics support is provided by Dr. Jonathan Pevsner at the Kennedy Krieger and also through the Genetic Resource Core facility at the John Hopkins University Medical Complex. The former will provide advice and specialized technical assistance such as for SSCP analysis and nucleic acid isolation while the latter facility will carry out the more usual services of oligonucleotide synthesis and DNA sequencing, among others.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD024061-14
Application #
6502540
Study Section
Project Start
2001-08-01
Project End
2002-07-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
14
Fiscal Year
2001
Total Cost
$131,864
Indirect Cost

  Institution

Name
Hugo W. Moser Research Institute Kennedy Krieger
Department
Type
DUNS #
167202410
City
Baltimore
State
MD
Country
United States
Zip Code
21205

  Publications

Jenkins, Edmund C; Ye, Lingling; Krinsky-McHale, Sharon J et al. (2016) Telomere longitudinal shortening as a biomarker for dementia status of adults with Down syndrome. Am J Med Genet B Neuropsychiatr Genet 171B:169-74
Schneider, Heather E; Lam, Janet C; Mahone, E Mark (2016) Sleep disturbance and neuropsychological function in young children with ADHD. Child Neuropsychol 22:493-506
Sweda, Romy; Phillips, Andre W; Marx, Joel et al. (2016) Glial-Restricted Precursors Protect Neonatal Brain Slices from Hypoxic-Ischemic Cell Death Without Direct Tissue Contact. Stem Cells Dev 25:975-85
Reinblatt, Shauna P; Leoutsakos, Jeannie-Marie S; Mahone, E Mark et al. (2015) Association between binge eating and attention-deficit/hyperactivity disorder in two pediatric community mental health clinics. Int J Eat Disord 48:505-11
Gaddis, Andrew; Rosch, Keri S; Dirlikov, Benjamin et al. (2015) Motor overflow in children with attention-deficit/hyperactivity disorder is associated with decreased extent of neural activation in the motor cortex. Psychiatry Res 233:488-95
Porambo, Michael; Phillips, Andre W; Marx, Joel et al. (2015) Transplanted glial restricted precursor cells improve neurobehavioral and neuropathological outcomes in a mouse model of neonatal white matter injury despite limited cell survival. Glia 63:452-65
Diehl, Adam; Mu, Weiyi; Batista, Denise et al. (2015) An atypical 0.73 MB microduplication of 22q11.21 and a novel SALL4 missense mutation associated with thumb agenesis and radioulnar synostosis. Am J Med Genet A 167:1644-9
Koriakin, Taylor A; Mahone, E Mark; Jacobson, Lisa A (2015) Sleep Difficulties are Associated with Parent Report of Sluggish Cognitive Tempo. J Dev Behav Pediatr 36:717-23
Reinblatt, Shauna P; Mahone, E Mark; Tanofsky-Kraff, Marian et al. (2015) Pediatric loss of control eating syndrome: Association with attention-deficit/hyperactivity disorder and impulsivity. Int J Eat Disord 48:580-8
Walsh, D M; Doran, E; Silverman, W et al. (2015) Rapid assessment of cognitive function in down syndrome across intellectual level and dementia status. J Intellect Disabil Res 59:1071-9

Showing the most recent 10 out of 376 publications