Abstract

The goals of this Core are to: (1) Measure """"""""small molecules"""""""" (primarily amino acids and biogenic amines) of central importance to brain chemistry. (2) Assay stable isotope enrichment with mass spectrometry in order to perform kinetic studies of metabolic flux, both in vitro and in people with developmental disabilifies. (3) Idenfify and characterize pepfides and proteins that are important to neurologic function. (4) Perform cell-based assays of physiologic processes that are important to brain funcfion, including assays of Ca2+, calpain, caspase and ROS;(5) Assist users with regard to experimental design and data interpretation. The rationale for the core is that neurochemical derangements occur in many developmental disabilifies, including metabolic diseases, hypoxic injury, epilepsy, neurotoxicity, etc.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
2P30HD026979-21
Application #
8038873
Study Section
Special Emphasis Panel (ZHD1-MRG-C (ID))
Project Start
2010-08-01
Project End
2015-06-30
Budget Start
2010-08-01
Budget End
2011-06-30
Support Year
21
Fiscal Year
2010
Total Cost
$227,363
Indirect Cost

  Institution

Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Kohls, Gregor; Antezana, Ligia; Mosner, Maya G et al. (2018) Altered reward system reactivity for personalized circumscribed interests in autism. Mol Autism 9:9
Yerys, Benjamin E; Herrington, John D; Bartley, Gregory K et al. (2018) Arterial spin labeling provides a reliable neurobiological marker of autism spectrum disorder. J Neurodev Disord 10:32
Maddox, Brenna B; Cleary, Patrick; Kuschner, Emily S et al. (2018) Lagging skills contribute to challenging behaviors in children with autism spectrum disorder without intellectual disability. Autism 22:898-906
Chapman, Kimberly A; Ostrovsky, Julian; Rao, Meera et al. (2018) Propionyl-CoA carboxylase pcca-1 and pccb-1 gene deletions in Caenorhabditis elegans globally impair mitochondrial energy metabolism. J Inherit Metab Dis 41:157-168
Glauser, Tracy A; Holland, Katherine; O'Brien, Valerie P et al. (2017) Pharmacogenetics of antiepileptic drug efficacy in childhood absence epilepsy. Ann Neurol 81:444-453
Herrington, John D; Maddox, Brenna B; McVey, Alana J et al. (2017) Negative Valence in Autism Spectrum Disorder: The Relationship Between Amygdala Activity, Selective Attention, and Co-occurring Anxiety. Biol Psychiatry Cogn Neurosci Neuroimaging 2:510-517
Monnerie, Hubert; Romer, Micah; Jensen, Brigid K et al. (2017) Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro. J Neurochem 140:53-67
Bangasser, D A; Dong, H; Carroll, J et al. (2017) Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling. Mol Psychiatry 22:1126-1133
Port, Russell G; Gaetz, William; Bloy, Luke et al. (2017) Exploring the relationship between cortical GABA concentrations, auditory gamma-band responses and development in ASD: Evidence for an altered maturational trajectory in ASD. Autism Res 10:593-607
Yerys, Benjamin E; Nissley-Tsiopinis, Jenelle; de Marchena, Ashley et al. (2017) Evaluation of the ADHD Rating Scale in Youth with Autism. J Autism Dev Disord 47:90-100

Showing the most recent 10 out of 318 publications