This application seeks support for the University of Iowa Child Health Research Center in response to RFA 90-HD-03. The proposal is to establish by the P30 grant mechanism a new center that will provide core support for laboratories and administrative resources applicable to a number of research projects. The theme of the Center will be the molecular biology of development. Encompassed by this theme are the identification and localization of genes on the human genome, mechanisms by which specific genes regulate the synthesis and timing of gene products, and the effects of gene products or their absence on the structure or function of developing tissues. The P.I., Program Director and 12 other Established Investigators whose funded research is closely related to the theme of the CHRC will act as an Advisory Committee to select initially from 9 highly qualified new faculty pediatrician scientists as many as 4-5 recipients of New Project Development Funds and/or one Pediatric Scientist recipient to support their research. Each of the 1090-91 candidates expects to conduct investigations appropriate to the CHRC theme, under the guidance of one or more identified Established Investigators. Each will perform certain molecular biologic procedures in a Shared Core Laboratory under the supervision of a Core Laboratory Director and with the technical help of an Assistant Research Scientist and Research Assistants. Young investigators supported by the Center also may spend other periods of time working in the laboratories of their respective Established Investigators. This arrangement will provide cost effective, quality-controlled, scientifically justified instrumentation and procedure performance of great utility to the recipients of support. Measures to attract women and minority pediatricians to research careers have been incorporated. The Center is anticipated to capitalize on an institutional infrastructure of interdisciplinary research. build upon a departmental tradition of research career development, promote productivity and collaboration, and speed the application of new basic science discoveries to clinical care.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD027748-02
Application #
3103043
Study Section
Special Emphasis Panel (SRC (LJ))
Project Start
1990-09-30
Project End
1995-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
2
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Iowa
Department
Type
Schools of Medicine
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Bonthius, Daniel J; Karacay, Bahri; Dai, De et al. (2004) The NO-cGMP-PKG pathway plays an essential role in the acquisition of ethanol resistance by cerebellar granule neurons. Neurotoxicol Teratol 26:47-57
Bonthius, Daniel J; Karacay, Bahri; Dai, De et al. (2003) FGF-2, NGF and IGF-1, but not BDNF, utilize a nitric oxide pathway to signal neurotrophic and neuroprotective effects against alcohol toxicity in cerebellar granule cell cultures. Brain Res Dev Brain Res 140:15-28
Bonthius, Daniel J; Karacay, Bahri (2003) Sydenham's chorea: not gone and not forgotten. Semin Pediatr Neurol 10:11-9
Schutte, Brian C; McCray Jr, Paul B (2002) [beta]-defensins in lung host defense. Annu Rev Physiol 64:709-48
Dickerson, Linda W; Bonthius, Daniel J; Schutte, Brian C et al. (2002) Altered GABAergic function accompanies hippocampal degeneration in mice lacking ClC-3 voltage-gated chloride channels. Brain Res 958:227-50
Scheetz, ToddE; Bartlett, Jennifer A; Walters, Jesse D et al. (2002) Genomics-based approaches to gene discovery in innate immunity. Immunol Rev 190:137-45
Schutte, Brian C; Mitros, Joseph P; Bartlett, Jennifer A et al. (2002) Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A 99:2129-33
Bonthius, Daniel J; Mahoney, Jolonda; Buchmeier, Michael J et al. (2002) Critical role for glial cells in the propagation and spread of lymphocytic choriomeningitis virus in the developing rat brain. J Virol 76:6618-35
Bonthius, Daniel J; Tzouras, Georgios; Karacay, Bahri et al. (2002) Deficiency of neuronal nitric oxide synthase (nNOS) worsens alcohol-induced microencephaly and neuronal loss in developing mice. Brain Res Dev Brain Res 138:45-59
Bonthius, D J; Pantazis, N J; Karacay, B et al. (2001) Alcohol exposure during the brain growth spurt promotes hippocampal seizures, rapid kindling, and spreading depression. Alcohol Clin Exp Res 25:734-45

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