Abstract

The UTMB Child Health Research Center for Developmental Immunobiology will provide a training environment for young pediatric scientists who wish to apply current basic science concepts and techniques to research concerning the health and diseases of children. A group of established investigators with basic science and clinical expertise related to developmental immunology will serve as mentors to the junior faculty trainees. Trainee projects in the areas of mucosal and nutritional immunology, immunodeficiency and the molecular biology of leukocytes, and neuroendocrine immunology will be supported by a number of established cross-disciplinary research programs. A Core Laboratory will provide technical support and training for state-of-the-art methodologies in molecular biology, cellular immunity and immune/protein chemistry. Trainees will also be supported by the Department of Pediatrics Research Facilitation Program, which assists junior faculty with research program planning, research design development, and grant and manuscript writing. Training objectives will be met through regular interactions between the young investigators and senior scientists in the laboratory, frequent informal and formal research presentations, and preparation with mentors of research protocols, manuscripts and grant proposals. The Center will foster a talented cadre of new pediatric scientists who will advance the application of immunologic concepts and methods to future studies of child health and disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD027841-05
Application #
2200674
Study Section
Special Emphasis Panel (SRC (LJ))
Project Start
1990-09-30
Project End
1997-11-30
Budget Start
1994-09-01
Budget End
1997-11-30
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Texas Medical Br Galveston
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555

  Publications

Endo, Shuichiro; Hochman, Daniel J; Midoro-Horiuti, Terumi et al. (2011) Mountain cedar pollen induces IgE-independent mast cell degranulation, IL-4 production, and intracellular reactive oxygen species generation. Cell Immunol 271:488-95
Midoro-Horiuti, Terumi; Schein, Catherine H; Mathura, Venkatarajan et al. (2006) Structural basis for epitope sharing between group 1 allergens of cedar pollen. Mol Immunol 43:509-18
Jamaluddin, Mohammad; Choudhary, Sanjeev; Wang, Shaofei et al. (2005) Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter. J Virol 79:15302-13
Czerwinski, Edmund W; Midoro-Horiuti, Terumi; White, Mark A et al. (2005) Crystal structure of Jun a 1, the major cedar pollen allergen from Juniperus ashei, reveals a parallel beta-helical core. J Biol Chem 280:3740-6
Dallas, Dara Varga; Keeney, Susan E; Mathews, Mary J et al. (2004) Effects of postnatal dexamethasone on oxygen toxicity in neonatal rats. Biol Neonate 86:145-54
Midoro-Horiuti, Terumi; Mathura, Venkatarajan; Schein, Catherine H et al. (2003) Major linear IgE epitopes of mountain cedar pollen allergen Jun a 1 map to the pectate lyase catalytic site. Mol Immunol 40:555-62
Liu, Dequin; Midoro-Horiuti, Terumi; White, Mark A et al. (2003) Crystallization and preliminary X-ray diffraction analysis of Jun a 1, the major allergen isolated from pollen of the mountain cedar Juniperus ashei. Acta Crystallogr D Biol Crystallogr 59:1052-4
Tian, Bing; Brasier, Allan R (2003) Identification of a nuclear factor kappa B-dependent gene network. Recent Prog Horm Res 58:95-130
Zhang, Yuhong; Jamaluddin, Mohammad; Wang, Shaofei et al. (2003) Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells. J Virol 77:5933-47
Kim, Shelly K; Keeney, Susan E; Alpard, ScotT K et al. (2003) Comparison of L-selectin and CD11b on neutrophils of adults and neonates during the first month of life. Pediatr Res 53:132-6

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