Abstract

The CHOP MAPS/CHRC Molecular Core, supervised by Beverly Emanuel Phd, and staffed by Steven Mahoney, Core Research Technician provides our MAPS/CHRC Scholars with access to up-to-date, well maintained laboratory facilities for analysis of DNA, RNA, proteins, cells and tissues, and with technical support and instruction to assist the Scholars in mastering the techniques of molecular biology. The Core is situated in the CHOP Abramson Research Building. It is fully equipped for oligonucleotide and protein synthesis and sequencing, gene localization, protein chemistry, and immunochemical/histochemical analysis of cells and tissues.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD028815-10
Application #
6564706
Study Section
Project Start
2001-12-01
Project End
2002-11-30
Budget Start
Budget End
Support Year
10
Fiscal Year
2002
Total Cost
$197,422
Indirect Cost

  Institution

Name
Children's Hospital of Philadelphia
Department
Type
DUNS #
073757627
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Shaikh, Tamim H; O'Connor, Ronald J; Pierpont, Mary Ella et al. (2007) Low copy repeats mediate distal chromosome 22q11.2 deletions: sequence analysis predicts breakpoint mechanisms. Genome Res 17:482-91
Saitta, Sulagna C; Harris, Stacy E; McDonald-McGinn, Donna M et al. (2004) Independent de novo 22q11.2 deletions in first cousins with DiGeorge/velocardiofacial syndrome. Am J Med Genet A 124A:313-7
Saitta, Sulagna C; Harris, Stacy E; Gaeth, Ann P et al. (2004) Aberrant interchromosomal exchanges are the predominant cause of the 22q11.2 deletion. Hum Mol Genet 13:417-28
Cron, Randy Q (2003) CD154 transcriptional regulation in primary human CD4 T cells. Immunol Res 27:185-202
Ming, J E; Elkan, M; Tang, K et al. (2002) Type I bone morphogenetic protein receptors are expressed on cerebellar granular neurons and a constitutively active form of the type IA receptor induces cerebellar abnormalities. Neuroscience 114:849-57
Maris, J M; Guo, C; White, P S et al. (2001) Allelic deletion at chromosome bands 11q14-23 is common in neuroblastoma. Med Pediatr Oncol 36:24-7
Maris, J M; Guo, C; Blake, D et al. (2001) Comprehensive analysis of chromosome 1p deletions in neuroblastoma. Med Pediatr Oncol 36:32-6
McVeigh, K E; Mallee, J J; Lucente, A et al. (2000) Murine chromosome 16 telomeric region, homologous with human chromosome 21q22, contains the osmoregulatory Na(+)/myo-inositol cotransporter (SLC5A3) gene. Cytogenet Cell Genet 88:153-8
Korimilli, A; Gonzales, L W; Guttentag, S H (2000) Intracellular localization of processing events in human surfactant protein B biosynthesis. J Biol Chem 275:8672-9
Guttentag, S H; Beers, M F; Bieler, B M et al. (1998) Surfactant protein B processing in human fetal lung. Am J Physiol 275:L559-66

Showing the most recent 10 out of 39 publications