Children's National Medical Center (CN) is submitting a competitive renewal for its Intellectual and Developmental Disabilities Research Center (IDDRC). The focus of this Center is on cellular, physiological and neurobehavioral aspects of brain development and dysfunction, and on the mechanisms of genetic diseases causing intellectual and other developmental disabilities. The Center comprises 151 NIH and other federally funded projects, with a total annual direct costs of more than $50 million, of which over $12 million is from NICHD. The projects that are part of the IDDRC cover 27 of the 31 areas of focus in the IDDRC RFA:HD-10-022. A total of 96 faculty members from 25 departments/divisions at the participating institutions (CN, GU, GWU, HU) are affiliated with the IDDRC as Center Investigators. We propose to support an Administrative Core (Administrative Core) and 5 scientific cores: Biostatistics and Informatics (Biostatistics and Informatics Core), Cellular Imaging (CIC), Proteomics and Genomics (PGC), Neuroimaging (NIC) and Neurobehavioral Evaluation (Neurobehavioral Evaluation Core). The Director of the IDDRC, Vittorio Gallo, Ph.D. is also Director of the Centerfor Neuroscience Research at CN, where he developed a research program on neurodevelopmental disorders. He will direct the Administrative Core that functions as the heart/coordinating core of the entire IDDRC. The Administrative Core will promote growth of the IDDRC by providing advocacy, management and administration, communication and training, compliance and quality assurance, strategic planning and recruitment. Biostatistics and Informatics Core provides a broad range of study design, information management, and statistical support services extending from the design of research studies to publication of results. CIC assists investigators with a broad array of imaging tools for cellular analysis, and provides advisory and training services. PGC provides advanced genomics and proteomics technologies, genetic counseling as well as specialized statistical analyses for DNA, mRNA and proteomics studies. NIC provides support for image acquisition, image sequence selection and implementation, paradigm design for functional studies, software development, image processing/analysis. Neurobehavioral Evaluation Core provides sophisticated neurobehavioral and neuropsychological research support to define developmental and behavioral phenotypes and to develop or validate new methods for this purpose. As demonstrated in the past funding cycle, the continued support to our IDDRC will further enhance recruitment of new IDD investigators, and will promote interdisciplinary IDDR to generate innovation, resulting in major advancements in IDDR.

Public Health Relevance

Intellectual and developmental disabilities (IDDs) affect 15% of children, but little is known of their neurological/neurobehavioral/genetic causes. Our IDD Research Center (IDDRC) includes multidisciplinary programs and supports investigators through unique, cost effective research Cores providing a broad range of current technologies. This research will improve our understanding of the causes underlying IDDs and develop innovative therapies, to permit each child to achieve full physical/intellectual potential.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Parisi, Melissa
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Research Institute
United States
Zip Code
Meert, Kathleen; Telford, Russell; Holubkov, Richard et al. (2018) Paediatric in-hospital cardiac arrest: Factors associated with survival and neurobehavioural outcome one year later. Resuscitation 124:96-105
Abou-Antoun, Tamara J; Nazarian, Javad; Ghanem, Anthony et al. (2018) Molecular and functional analysis of anchorage independent, treatment-evasive neuroblastoma tumorspheres with enhanced malignant properties: A possible explanation for radio-therapy resistance. PLoS One 13:e0189711
Ratto, Allison B; Kenworthy, Lauren; Yerys, Benjamin E et al. (2018) What About the Girls? Sex-Based Differences in Autistic Traits and Adaptive Skills. J Autism Dev Disord 48:1698-1711
Slomine, Beth S; Silverstein, Faye S; Christensen, James R et al. (2018) Neurobehavioural outcomes in children after In-Hospital cardiac arrest. Resuscitation 124:80-89
Turesky, Ted K; Olulade, Olumide A; Luetje, Megan M et al. (2018) An fMRI study of finger tapping in children and adults. Hum Brain Mapp 39:3203-3215
Taylor, C M; Olulade, O A; Luetje, M M et al. (2018) An fMRI study of coherent visual motion processing in children and adults. Neuroimage 173:223-239
Meert, Kathleen; Slomine, Beth S; Christensen, James R et al. (2018) Burden of caregiving after a child's in-hospital cardiac arrest. Resuscitation 127:44-50
Maddox, Brenna B; Cleary, Patrick; Kuschner, Emily S et al. (2018) Lagging skills contribute to challenging behaviors in children with autism spectrum disorder without intellectual disability. Autism 22:898-906
Val, St├ęphanie; Krueger, Anna; Poley, Marian et al. (2018) Nontypeable Haemophilus influenzae lysates increase heterogeneous nuclear ribonucleoprotein secretion and exosome release in human middle-ear epithelial cells. FASEB J 32:1855-1867
Uittenbogaard, Martine; Brantner, Christine A; Chiaramello, Anne (2018) Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells. Cell Death Dis 9:360

Showing the most recent 10 out of 349 publications