A. Objective The IDDRC Neuroimaging Core provides support for all aspects of human neuroimaging research necessary for the IDDRC mission. The core supports a growing group of investigators that have unique experience in imaging normal brain development and children with a wide range of intellectual and developmental disabilities. We also place an emphasis on young investigator development. Advanced neuroimaging technology provides a critical means for evaluating the structural anatomy, biochemistry, and functional anatomical abnormalities that underlie developmental disabilities in addition to identifying disease/disorder biomarkers. Furthermore, imaging provides objective measures for examining the consequences of these disorders on brain structure and function, and providing a non-invasive means for exploring human neuroplasticity, adaptation in response to disease, and response to neuro-intervention. The Neuroimage Core: 1. Provides consultation in identifying efficient and effective imaging protocols to investigate experimental questions in specific clinical populations and during normal development 2. Provides consultation in processing and data analysis of structural and functional MRI scans in studies designed to detect alterations in brain structure, connectivity, or regional cortical activation 3. Provides access to and specific training in the use of the 3.0T MRI systems for structural, functional, and metabolic imaging 4. Supports investigators in developing and utilizing functional imaging tasks (""""""""paradigms"""""""") focusing on visual, auditory, and sensorimotor processing, memory, language, executive function, and visuospatial skills, among others 5. Implements and supports techniques to desensitize anxious research subjects to the staff, settings, equipment and procedures associated with neuroimaging 6. Assists in selection, and implementation, and interpretation of statistical plan (with statistical core) 7. Performs imaging assessments of children, adolescents and adults 8. Assists in manuscript preparation for studies involving imaging 9. Assists in the monitoring of outcomes (efficacy, safety) in clinical trials utilizing imaging measures 10. Provides support and training for new investigators (and research assistants/personnel) entering the neuroimaging field.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD040677-14
Application #
8733077
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Children's Research Institute
Department
Type
DUNS #
City
Washington
State
DC
Country
United States
Zip Code
20052
Taylor, C M; Olulade, O A; Luetje, M M et al. (2018) An fMRI study of coherent visual motion processing in children and adults. Neuroimage 173:223-239
Meert, Kathleen; Slomine, Beth S; Christensen, James R et al. (2018) Burden of caregiving after a child's in-hospital cardiac arrest. Resuscitation 127:44-50
Maddox, Brenna B; Cleary, Patrick; Kuschner, Emily S et al. (2018) Lagging skills contribute to challenging behaviors in children with autism spectrum disorder without intellectual disability. Autism 22:898-906
Val, St├ęphanie; Krueger, Anna; Poley, Marian et al. (2018) Nontypeable Haemophilus influenzae lysates increase heterogeneous nuclear ribonucleoprotein secretion and exosome release in human middle-ear epithelial cells. FASEB J 32:1855-1867
Uittenbogaard, Martine; Brantner, Christine A; Chiaramello, Anne (2018) Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells. Cell Death Dis 9:360
Cardinale, Elise M; Breeden, Andrew L; Robertson, Emily L et al. (2018) Externalizing behavior severity in youths with callous-unemotional traits corresponds to patterns of amygdala activity and connectivity during judgments of causing fear. Dev Psychopathol 30:191-201
Zamarbide, Marta; Oaks, Adam W; Pond, Heather L et al. (2018) Loss of the Intellectual Disability and Autism GeneCc2d1aand Its HomologCc2d1bDifferentially Affect Spatial Memory, Anxiety, and Hyperactivity. Front Genet 9:65
Cornell, Timothy T; Selewski, David T; Alten, Jeffrey A et al. (2018) Acute kidney injury after out of hospital pediatric cardiac arrest. Resuscitation 131:63-68
Scafidi, Joseph; Ritter, Jonathan; Talbot, Brooke M et al. (2018) Age-Dependent Cellular and Behavioral Deficits Induced by Molecularly Targeted Drugs Are Reversible. Cancer Res 78:2081-2095
Uittenbogaard, Martine; Brantner, Christine A; Fang, ZiShui et al. (2018) Novel insights into the functional metabolic impact of an apparent de novo m.8993T>G variant in the MT-ATP6 gene associated with maternally inherited form of Leigh Syndrome. Mol Genet Metab 124:71-81

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