Abstract

The mouse Genetic services aspect of this Model Organisms Core is widely used core service by MRDDRC investigators and serves an essential service to the MRDD community. The MRDDRC will partner with the existing Biological Sciences Divisional Core to provide transgenic and targeted mutagenesis services to MRDDRC investigators. By partnering with the existing Divisional core, the MRDDRC grant strengthens the already successful core. MRDDRC investigators will gain a subsidy services through this core. MRDDRC funding of the divisional core also allows the addition of ES cell culturing services and gene targeting - services not currently available in the Divisional Mouse Core. Further, the MRDDRC investigators will have available the expertise of both MRDDRC co-directors - both accomplished mouse geneticists with extensive neurobiological expertise. The co-directors will provide project design consultation, vector design expertise and advice for analysis. The co-directors are familiar with the research programs of all MRDDRC users and can facilitate interactions between investigators for reagent sharing and collaborations for further analysis. The codirectors will also refer users to other MRDDRC cores for additional analysis of mouse models generated, including the new Mouse Phenotyping Subcore.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Center Core Grants (P30)
Project #
5P30HD054275-04
Application #
7906015
Study Section
Special Emphasis Panel (ZHD1)
Project Start
Project End
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
4
Fiscal Year
2009
Total Cost
$186,624
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Domowicz, Miriam; Wadlington, Natasha L; Henry, Judith G et al. (2018) Glial cell responses in a murine multifactorial perinatal brain injury model. Brain Res 1681:52-63
Kara, Sam; Pirela-Morillo, Gerardo A; Gilliam, Conrad T et al. (2018) Identification of novel susceptibility genes associated with seven autoimmune disorders using whole genome molecular interaction networks. J Autoimmun :
Cortes, Mauricio; Cortes, Leslie K; Schwartz, Nancy B (2015) Mapping proteoglycan functions with glycosidases. Methods Mol Biol 1229:443-55
Foxley, Sean; Domowicz, Miriam; Karczmar, Gregory S et al. (2015) 3D high spectral and spatial resolution imaging of ex vivo mouse brain. Med Phys 42:1463-72
Chen, Jen-Hao; Claessens, Amy; Msall, Michael E (2014) Prematurity and school readiness in a nationally representative sample of Australian children: does typically occurring preschool moderate the relationship? Early Hum Dev 90:73-9
Frisch, Dana; Msall, Michael E (2013) Health, functioning, and participation of adolescents and adults with cerebral palsy: a review of outcomes research. Dev Disabil Res Rev 18:84-94
Shandra, Carrie L; Avery, Roger C; Hogan, Dennis P et al. (2012) Child and adult disability in the 2000 Census: disability is a household affair. Disabil Health J 5:241-8
Msall, Michael E (2012) Helping parents of children with monogenetic disorders understand developmental trajectories: lessons from achondroplasia. Dev Med Child Neurol 54:488-9
Shah, Reshma P; Spruyt, Karen; Kragie, Brigette C et al. (2012) Visuomotor performance in KCNJ11-related neonatal diabetes is impaired in children with DEND-associated mutations and may be improved by early treatment with sulfonylureas. Diabetes Care 35:2086-8
Msall, Michael E (2011) A tool kit for measuring functioning in children with neurodisability: calibrating activities. Dev Med Child Neurol 53:1073-4

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