Abstract

This Special Mental Health-Clinical Research Center grant renewal application proposes long-term support for an ongoing program of research on the classification and course of the schizophrenias conducted at the Maryland Psychiatric Research Center. The assumption that schizophrenia is heterogeneous with respect to etiology, manifestations, and course forms a basis for a comprehensive scientific approach to the differentiation and characterization of various subtypes of the disorder. Patients are drawn from the Inpatient and Outpatient Programs of the Maryland Psychiatric Research Center. Support services for SMH-CRC investigators will be provided through the following five modules, or cores: Scientific Support, Assessment, Data Management, Clinical Biology, and Subject Recruitment. A separately funded Training component is also an integral part of the proposed program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
2P30MH040279-07
Application #
3103208
Study Section
Neuroscience Subcommittee (MHSP)
Project Start
1986-02-15
Project End
1998-07-31
Budget Start
1993-09-30
Budget End
1994-07-31
Support Year
7
Fiscal Year
1993
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Type
Schools of Medicine
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Warren, Kimberly R; Ball, M Patricia; Feldman, Stephanie et al. (2011) Exercise program adherence using a 5-kilometer (5K) event as an achievable goal in people with schizophrenia. Biol Res Nurs 13:383-90
Gao, Xue-Min; Elmer, Gregory I; Adams-Huet, Beverley et al. (2009) Social memory in mice: disruption with an NMDA antagonist and attenuation with antipsychotic drugs. Pharmacol Biochem Behav 92:236-42
Kelly, Deanna L; Wehring, Heidi J; Linthicum, Jared et al. (2009) Cardiac-related findings at autopsy in people with severe mental illness treated with clozapine or risperidone. Schizophr Res 107:134-8
Lahti, Adrienne C; Weiler, Martin A; Holcomb, Henry H et al. (2009) Modulation of limbic circuitry predicts treatment response to antipsychotic medication: a functional imaging study in schizophrenia. Neuropsychopharmacology 34:2675-90
Lahti, Adrienne C; Weiler, Martin A; Holcomb, Henry H et al. (2006) Correlations between rCBF and symptoms in two independent cohorts of drug-free patients with schizophrenia. Neuropsychopharmacology 31:221-30
Lahti, Adrienne C; Weiler, Martin A; Medoff, Deborah R et al. (2005) Functional effects of single dose first- and second-generation antipsychotic administration in subjects with schizophrenia. Psychiatry Res 139:19-30
McMahon, Robert P; Arndt, Stephan; Conley, Robert R (2005) More powerful two-sample tests for differences in repeated measures of adverse effects in psychiatric trials when only some patients may be at risk. Stat Med 24:11-21
Wilk, Christopher M; Gold, James M; Humber, Kathy et al. (2004) Brief cognitive assessment in schizophrenia: normative data for the Repeatable Battery for the Assessment of Neuropsychological Status. Schizophr Res 70:175-86
Lahti, Adrienne C; Holcomb, Henry H; Weiler, Martin A et al. (2004) Clozapine but not haloperidol Re-establishes normal task-activated rCBF patterns in schizophrenia within the anterior cingulate cortex. Neuropsychopharmacology 29:171-8
Lahti, Adrienne C; Holcomb, Henry H; Weiler, Martin A et al. (2003) Functional effects of antipsychotic drugs: comparing clozapine with haloperidol. Biol Psychiatry 53:601-8

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