Abstract

Overall Aims 1. To examine basic technical and methodical issues involved in PET and fMR imaging of cognitive function. 2. To apply multiple injection [150]water PET and fMRI protocols in order to map systems involved in cognitive operations or functions such as timing, planning, sequencing, attention, language, emotion, and memory. 3. To apply them to the study of cognition in healthy normal individuals. 4. To apply them in order to explore disturbances in cognitive function that occur in mental illnesses that are hypothesized to have neurodevelopmental origins (i.e., schizophrenia and autism), as well as disturbances in cognitive function that result from focal vascular lesions. 5. To use them to explore disturbances in cognitive function resulting from acute and chronic use of addictive, psychoactive substances such as nicotine, marijuana and alcohol.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
2P30MH043271-13
Application #
6204805
Study Section
Project Start
1999-09-30
Project End
2000-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
13
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Rudd, Danielle S; Axelsen, Michael; Epping, Eric A et al. (2014) A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model. Am J Med Genet B Neuropsychiatr Genet 165B:619-26
Parker, Krystal L; Andreasen, Nancy C; Liu, Dawei et al. (2013) Eyeblink conditioning in unmedicated schizophrenia patients: a positron emission tomography study. Psychiatry Res 214:402-9
Onwuameze, O E; Nam, K W; Epping, E A et al. (2013) MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse. Psychol Med 43:619-31
Andreasen, Nancy C; Liu, Dawei; Ziebell, Steven et al. (2013) Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study. Am J Psychiatry 170:609-15
Salinas, Joel; Mills, Elizabeth D; Conrad, Amy L et al. (2012) Sex differences in parietal lobe structure and development. Gend Med 9:44-55
Wassink, Thomas H; Epping, Eric A; Rudd, Danielle et al. (2012) Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. Arch Gen Psychiatry 69:885-92
Andreasen, N C; Wilcox, M A; Ho, B-C et al. (2012) Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes. Mol Psychiatry 17:1093-102
Andreasen, Nancy C; Nopoulos, Peg; Magnotta, Vincent et al. (2011) Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia. Biol Psychiatry 70:672-9
Ho, Beng-Choon; Wassink, Thomas H; Ziebell, Steven et al. (2011) Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. Schizophr Res 128:66-75
Pierson, Ronald; Johnson, Hans; Harris, Gregory et al. (2011) Fully automated analysis using BRAINS: AutoWorkup. Neuroimage 54:328-36

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