Abstract

Overall Aims 1. To examine the effects of typical and atypical anti-psychotics on the neuroanatomic substrates of schizophrenia and determine their relative effects of cognitive performance. 2. To examine the effects of typical and atypical anti-psychotics on functional measures of cerebellar activity while performing motor tasks. 3. To examine the influence of gene expression at the CYP2D6 liver enzymes on pharmacokinetics of anti-psychotic medications and apply principles of pharmacokinetics to identify optimum anti-psychotic doses. 4. To explore the efficacy of typical and atypical anti-psychotics in the treatment of the psychotic, disorganized, and negative symptom dimensions in schizophrenia. 5. To determine whether receptor polymorphisms at the 5-HT/2a and 5- HT/2c receptors predict therapeutic response to atypical anti-psychotics. 6. To explore why some patients with schizophrenia develop neuroleptic induced motor disturbances, such as tardive dyskinesia (TD) and to determine the relative influences of various risk factors for TD. 7. To use MR imaging to examine the long-term effects of anti-psychotics on brain plasticity through the assessment of subtle structural changes in a longitudinal design.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH043271-14
Application #
6344967
Study Section
Project Start
2000-09-01
Project End
2001-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
14
Fiscal Year
2000
Total Cost
$111,111
Indirect Cost

  Institution

Name
University of Iowa
Department
Type
DUNS #
041294109
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Rudd, Danielle S; Axelsen, Michael; Epping, Eric A et al. (2014) A genome-wide CNV analysis of schizophrenia reveals a potential role for a multiple-hit model. Am J Med Genet B Neuropsychiatr Genet 165B:619-26
Parker, Krystal L; Andreasen, Nancy C; Liu, Dawei et al. (2013) Eyeblink conditioning in unmedicated schizophrenia patients: a positron emission tomography study. Psychiatry Res 214:402-9
Onwuameze, O E; Nam, K W; Epping, E A et al. (2013) MAPK14 and CNR1 gene variant interactions: effects on brain volume deficits in schizophrenia patients with marijuana misuse. Psychol Med 43:619-31
Andreasen, Nancy C; Liu, Dawei; Ziebell, Steven et al. (2013) Relapse duration, treatment intensity, and brain tissue loss in schizophrenia: a prospective longitudinal MRI study. Am J Psychiatry 170:609-15
Andreasen, N C; Wilcox, M A; Ho, B-C et al. (2012) Statistical epistasis and progressive brain change in schizophrenia: an approach for examining the relationships between multiple genes. Mol Psychiatry 17:1093-102
Salinas, Joel; Mills, Elizabeth D; Conrad, Amy L et al. (2012) Sex differences in parietal lobe structure and development. Gend Med 9:44-55
Wassink, Thomas H; Epping, Eric A; Rudd, Danielle et al. (2012) Influence of ZNF804a on brain structure volumes and symptom severity in individuals with schizophrenia. Arch Gen Psychiatry 69:885-92
Andreasen, Nancy C; Nopoulos, Peg; Magnotta, Vincent et al. (2011) Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia. Biol Psychiatry 70:672-9
Ho, Beng-Choon; Wassink, Thomas H; Ziebell, Steven et al. (2011) Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. Schizophr Res 128:66-75
Pierson, Ronald; Johnson, Hans; Harris, Gregory et al. (2011) Fully automated analysis using BRAINS: AutoWorkup. Neuroimage 54:328-36

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