Promising new tools for HIV prevention and treatment have stimulated global initiatives to ?End the HIV Epidemic? and reach the ?End of AIDS;? however, significant challenges to ending the global HIV epidemic remain. Biomedical advances for prevention and treatment will not reach their full potential without rigorous behavioral and social science research to optimize uptake, adherence, and equitable and effective implementation and scale-up. Thus, we propose a renewed HIV Center for Clinical and Behavioral Studies that expands on our history of conducting interdisciplinary HIV research and leverages new partnerships to maximize the potential of biomedical advances, addressing their availability and acceptability to the most vulnerable populations. The HIV Center is unique among NIMH AIDS Research Centers (ARCs) in being based in New York City (NYC), a continuing US AIDS epicenter in a state that has the greatest number of people living with HIV (PLWH) in the US, including ethnic/racial minority populations coping with extreme economic, health, and social disparities. In 2014, HIV Center investigators and other academicians, providers, advocates, and policy-makers joined the Office of the Governor of New York State (NYS) to develop a NYS Blueprint for Ending the Epidemic (EtE). The Blueprint provides the HIV Center with the unique opportunity to use our home city and state as a ?laboratory? to study implementation of EtE initiatives and apply lessons learned to US and global epidemics. Thus, in the next five years, the HIV Center will be guided by the theme, The Science of Ending the HIV/AIDS Epidemic (EtE): Efficacy to Effectiveness at Scale, and its emphasis on implementation research and research at the intersection of behavioral, social, and biomedical sciences. The HIV Center brings together a cadre of investigators at the forefront of multiple disciplines to address three Specific Aims: (1) to catalyze intervention and implementation science research necessary to achieve EtE goals; (2) to translate research into culturally and structurally competent practice and policy for maximum public health impact; and (3) to increase the capacity of current and future generations of scientists, service providers, and community and policy leaders to create and implement biomedical, behavioral, social, and structural HIV prevention and treatment interventions to meet EtE goals. Our Cores ensure methodological and theoretical rigor, identify and rapidly respond to new trends in the epidemic, support critical research- practice partnerships, and train new scientists. We complement the Administrative and Development Cores with three Research Cores: (1) Statistics, Assessment, and Data Management (StAD) Core, focused on innovative analytic, assessment, and data management strategies; (2) Bio-Behavioral Core, focused on research at the interface of the biomedical and the behavioral and social sciences; and (3) Implementation Science and Health Outcomes (ISHO) Core focused on effective, sustained, and equitable achievement of HIV prevention and care outcomes at scale.

Public Health Relevance

The HIV Center will continue as a global leader in HIV prevention and the fight to improve health outcomes and reduce HIV-related health and social disparities that disproportionately burden the most vulnerable ? women, youth, racial/ethnic and sexual minority populations, and other disenfranchised groups. We will work to meet ?Ending the HIV Epidemic? goals by synergizing institutional and intellectual resources; invigorating our multidisciplinary community of scientists, clinicians, and policy-makers; rigorously training a new generation of scientists; supporting research partnerships with public health policy and practice sectors; and translating transformative NIH-supported HIV/AIDS research into real-world practice and policy. We will apply the lessons learned from our research to improve the health and well being of all affected by the HIV epidemic, regardless of where they reside.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
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Special Emphasis Panel (ZMH1)
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Gordon, Christopher M
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New York State Psychiatric Institute
New York
United States
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Balán, Iván C; Frasca, Timothy; Dolezal, Curtis et al. (2018) HIV Risk Reduction by Avoiding Sex With Partners Unwilling to Undergo HIV Testing Is Not Coercion. J Acquir Immune Defic Syndr 78:e38
Brown 3rd, William; Giguere, Rebecca; Sheinfil, Alan et al. (2018) Challenges and solutions implementing an SMS text message-based survey CASI and adherence reminders in an international biomedical HIV PrEP study (MTN 017). J Biomed Inform 80:78-86
Benson, Stephanie; Elkington, Katherine S; Leu, Cheng-Shiun et al. (2018) Association Between Psychiatric Disorders, Substance Use, and Sexual Risk Behaviors in Perinatally HIV-Exposed Youth. J Assoc Nurses AIDS Care 29:538-549
Kelvin, Elizabeth A; George, Gavin; Mwai, Eva et al. (2018) Offering self-administered oral HIV testing to truck drivers in Kenya to increase testing: a randomized controlled trial. AIDS Care 30:47-55
Balán, Iván C; Giguere, Rebecca; Brown 3rd, William et al. (2018) Brief Participant-Centered Convergence Interviews Integrate Self-Reports, Product Returns, and Pharmacokinetic Results to Improve Adherence Measurement in MTN-017. AIDS Behav 22:986-995
Parcesepe, Angela M; Tymejczyk, Olga; Remien, Robert et al. (2018) Psychological distress, health and treatment-related factors among individuals initiating ART in Oromia, Ethiopia. AIDS Care 30:338-342
Iribarren, Sarah J; Ghazzawi, Alhasan; Sheinfil, Alan Z et al. (2018) Mixed-Method Evaluation of Social Media-Based Tools and Traditional Strategies to Recruit High-Risk and Hard-to-Reach Populations into an HIV Prevention Intervention Study. AIDS Behav 22:347-357
Barnes, David M; Des Jarlais, Don C; Wolff, Margaret et al. (2018) A qualitative study of persons who inject drugs but who have never helped others with first injections: how their views on helping contrast with the views of persons who have helped with first injections, and implications for interventions. Harm Reduct J 15:43
Masvawure, Tsitsi B; Mantell, Joanne E; Tocco, Jack Ume et al. (2018) Intentional and Unintentional Condom Breakage and Slippage in the Sexual Interactions of Female and Male Sex Workers and Clients in Mombasa, Kenya. AIDS Behav 22:637-648
Zhang, Yinfeng; Fogel, Jessica M; Guo, Xu et al. (2018) Antiretroviral drug use and HIV drug resistance among MSM and transgender women in sub-Saharan Africa. AIDS 32:1301-1306

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