This Core focuses on antidepressant studies and is particularly concerned with the assay of nortriptyline and paroxetine platelet 5-HT reuptake interrupted by the use of antidepressant medication, including a double- blind study of paroxetine, a potent innovative serotonin reuptake inhibitor versus the more generally used nortriptyline. The goal of the study is to document pharmacokinetic changes in elderly adults. one primary goal of the present Core is to provide support for other cores and relevant projects of the investigators focused on pharmacokinetic/pharmacodynamic assessments, and to provide relevant instruction for students and area nursing homes, in vivo (phenotyping) and in vitro (drug metabolic assays) studies of cytochrome P450 function, an enzyme responsible for metabolism of significant antidepressants.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
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University of Pittsburgh
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Smagula, Stephen F; Beach, Scott; Rosso, Andrea L et al. (2017) Brain Structural Markers and Caregiving Characteristics as Interacting Correlates of Caregiving Strain. Am J Geriatr Psychiatry 25:582-591
Smagula, Stephen F; Wallace, Meredith L; Anderson, Stewart J et al. (2016) Combining moderators to identify clinical profiles of patients who will, and will not, benefit from aripiprazole augmentation for treatment resistant late-life major depressive disorder. J Psychiatr Res 81:112-8
Khalaf, Alexander; Edelman, Kathryn; Tudorascu, Dana et al. (2015) White Matter Hyperintensity Accumulation During Treatment of Late-Life Depression. Neuropsychopharmacology 40:3027-35
Patel, Meenal J; Andreescu, Carmen; Price, Julie C et al. (2015) Machine learning approaches for integrating clinical and imaging features in late-life depression classification and response prediction. Int J Geriatr Psychiatry 30:1056-67
Joel, Ian; Begley, Amy E; Mulsant, Benoit H et al. (2014) Dynamic prediction of treatment response in late-life depression. Am J Geriatr Psychiatry 22:167-76
Diniz, Breno S; Reynolds 3rd, Charles F; Butters, Meryl A et al. (2014) The effect of gender, age, and symptom severity in late-life depression on the risk of all-cause mortality: the BambuĂ­ Cohort Study of Aging. Depress Anxiety 31:787-95
Andreescu, Carmen; Teverovsky, Esther; Fu, Bo et al. (2014) Old worries and new anxieties: behavioral symptoms and mild cognitive impairment in a population study. Am J Geriatr Psychiatry 22:274-84
Chisholm, Denise; Toto, Pamela; Raina, Ketki et al. (2014) Evaluating capacity to live independently and safely in the community: Performance Assessment of Self-care Skills. Br J Occup Ther 77:59-63
Gallo, Joseph J; Morales, Knashawn H; Bogner, Hillary R et al. (2013) Long term effect of depression care management on mortality in older adults: follow-up of cluster randomized clinical trial in primary care. BMJ 346:f2570
Sherer, Eric A; Sale, Mark E; Pollock, Bruce G et al. (2012) Application of a single-objective, hybrid genetic algorithm approach to pharmacokinetic model building. J Pharmacokinet Pharmacodyn 39:393-414

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