Abstract

The Clinical Virology Core Laboratory is intended to represent an integral component of UCSF Center for AIDS Research (CFAR) by providing state-of-the-art resources to the local community of HIV researchers for: To ensure the facilities and equipment to perform state-of-the-art virologic evaluations of clinical samples. To provide expertise, facilities, and assistance for the isolation and propagation of IV from clinical samples. To provide expertise, facilities and assistance for the quantitative determination of viral burden extant in clinical samples. To maintain and further develop methods to evaluate the sensitivity of HIV isolates to experimental antiviral agents. To continue to develop and disseminate virologic methods for the detailed investigation of the natural history and treatment of HIV infection. To continue intralaboratory QC/QA standards and procedures. Given the close intellectual and physical relationship of the proposed CFAR Core Facilities, we expect that the synergistic interactions that have emerged over the past two years will continue to flourish.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH059037-13
Application #
6302658
Study Section
Project Start
2000-03-15
Project End
2001-02-28
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
13
Fiscal Year
2000
Total Cost
$349,258
Indirect Cost

  Institution

Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143

  Publications

Josefsson, Lina; von Stockenstrom, Susanne; Faria, Nuno R et al. (2013) The HIV-1 reservoir in eight patients on long-term suppressive antiretroviral therapy is stable with few genetic changes over time. Proc Natl Acad Sci U S A 110:E4987-96
Josefsson, Lina; Eriksson, Susanne; Sinclair, Elizabeth et al. (2012) Hematopoietic precursor cells isolated from patients on long-term suppressive HIV therapy did not contain HIV-1 DNA. J Infect Dis 206:28-34
Papasavvas, Emmanouil; Hsue, Priscilla; Reynolds, Griffin et al. (2012) Increased CD34+/KDR+ cells are not associated with carotid artery intima-media thickness progression in chronic HIV-positive subjects. Antivir Ther 17:557-63
Hunt, Peter W; Landay, Alan L; Sinclair, Elizabeth et al. (2011) A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. PLoS One 6:e15924
Hunt, Peter W; Hatano, Hiroyu; Sinclair, Elizabeth et al. (2011) HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers. Clin Infect Dis 52:681-7
Hunt, Peter W; Cao, Huyen L; Muzoora, Conrad et al. (2011) Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy. AIDS 25:2123-31
Kitchen, Christina M R; Yeghiazarian, Lilit; Hoh, Rebecca et al. (2011) Immune activation, CD4+ T cell counts, and viremia exhibit oscillatory patterns over time in patients with highly resistant HIV infection. PLoS One 6:e21190
Favre, David; Stoddart, Cheryl A; Emu, Brinda et al. (2011) HIV disease progression correlates with the generation of dysfunctional naive CD8(low) T cells. Blood 117:2189-99
Hunt, Peter W; Martin, Jeffrey N; Sinclair, Elizabeth et al. (2011) Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis 203:1474-83
Favre, David; Mold, Jeff; Hunt, Peter W et al. (2010) Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med 2:32ra36

Showing the most recent 10 out of 157 publications