The Scripps NeuroAIDS Preclinical Studies (SNAPS) Center has been organized in order to allow the continuation and expansion of an innovative cross-disciplinary program of research at The Scripps Research Institute (TSRI) focusing on modeling untoward effects of HIV on the central nervous system (CNS). The spirit of the proposed CSPAR is to build on this history and continue to recruit from among the outstanding investigators in many aspects of basic immune and nervous system function whose research and expertise, if applied to the problems occurring in NeuroAIDS, could significantly improve our understanding of this condition. The overall goal of the Development Core is to award grants that will serve the purpose of stimulating new insights into the CNS damaged induced by HIV infection. Awards will take the form of small grants (approximately $40,000 direct costs per year), not to exceed two years total duration. It is expected that this initial funding will provide an opportunity to generate preliminary findings to support future application for NIH grant funds. Three major categories of applications will be considered for funding by the Core: 1) New investigators seeks to establish research programs in the area of NeuroAIDS, 2) Established investigators of diverse background that have no track record in NeuroAIDS and 3) Researchers established in NeuroAIDS, but proposing research that represents a significant departure from previous work. Applications will be evaluated by a panel, headed by the Core PI, comprised of members from both inside and outside TSRI. Criteria for selection for funding will include the overall scientific merit of the proposed work; the relevance to NeuroAIDS and fulfillment of the CSPAR aim to stimulate inter- and multi-disciplinary collaborations for research on the mental health issues of HIV infection; and the likelihood for success given the credentials of the investigator and the specific research environment. TSRI is uniquely suited to bring together scientists of diverse experience and background to carry out innovative research relevant to NeuroAIDS. As such, the potential is high for generating new ideas and fresh approaches to understanding mechanisms of lentivirus invasion of the CNS as well as to develop intervention strategies and therapeutic approaches to block, limit, and/or control infection of the CNS.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH062261-02
Application #
6504179
Study Section
Special Emphasis Panel (ZMH1)
Project Start
2001-09-01
Project End
2002-08-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Sathyanesan, Monica; Watt, Michael J; Haiar, Jacob M et al. (2018) Carbamoylated erythropoietin modulates cognitive outcomes of social defeat and differentially regulates gene expression in the dorsal and ventral hippocampus. Transl Psychiatry 8:113
Zhou, Tian; Su, Hang; Dash, Prasanta et al. (2018) Creation of a nanoformulated cabotegravir prodrug with improved antiretroviral profiles. Biomaterials 151:53-65
Thangaraj, Annadurai; Periyasamy, Palsamy; Liao, Ke et al. (2018) HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy. Autophagy 14:1596-1619
Kevadiya, Bhavesh D; Ottemann, Brendan M; Thomas, Midhun Ben et al. (2018) Neurotheranostics as personalized medicines. Adv Drug Deliv Rev :
Wiesman, Alex I; O'Neill, Jennifer; Mills, Mackenzie S et al. (2018) Aberrant occipital dynamics differentiate HIV-infected patients with and without cognitive impairment. Brain 141:1678-1690
Periyasamy, Palsamy; Thangaraj, Annadurai; Guo, Ming-Lei et al. (2018) Epigenetic Promoter DNA Methylation of miR-124 Promotes HIV-1 Tat-Mediated Microglial Activation via MECP2-STAT3 Axis. J Neurosci 38:5367-5383
Zhou, Tian; Lin, Zhiyi; Puligujja, Pavan et al. (2018) Optimizing the preparation and stability of decorated antiretroviral drug nanocrystals. Nanomedicine (Lond) 13:871-885
Yang, Lu; Niu, Fang; Yao, Honghong et al. (2018) Exosomal miR-9 Released from HIV Tat Stimulated Astrocytes Mediates Microglial Migration. J Neuroimmune Pharmacol 13:330-344
Lin, Zhiyi; Gautam, Nagsen; Alnouti, Yazen et al. (2018) ProTide generated long-acting abacavir nanoformulations. Chem Commun (Camb) 54:8371-8374
McMillan, JoEllyn; Szlachetka, Adam; Zhou, Tian et al. (2018) Pharmacokinetic testing of a first generation cabotegravir prodrug in rhesus macaques. AIDS :

Showing the most recent 10 out of 374 publications