The major goal of the Physiology Core of the Scripps NeuroAIDS Preclinical Studies (SNAPS), CSPAR, is tocontinue to provide neurophysiological assessment of AIDS-related functional pathology using a variety ofestablished and new animal models with clinical phenotypes relevant for neuroAIDS. The Core services willinclude continued evaluation of current primate and feline models infected with the analogous lentivirus (SIVand FIV, respectively) as well as assessment of existing and new mouse models representing molecularlyengineered phenotypes relevant for HIV-1 infection. The Core will provide a broad spectrum of analyses forthe detection of functional disease progression and identification of underlying mechanisms. In addition, theCore will work to recruit new SNAPS collaborators who will further enrich the assessment potential of theCore and its contribution to the neuroAIDS field. The Core is organized into two interacting units that carryout specific scientific analyses. The analyses provide sensitive measures of disease progression, functionaldeficits and underlying mechanisms. The in vivo analysis unit will carry out studies in mouse, primate andfeline models of NeuroAIDS utilizing in vivo techniques including extracellular single unit electrophysiologicalrecording, sensory potential recording and radio telemetry. The in vitro analysis unit will useelectrophysiological recordings of brain slices from animal models of NeuroAIDS or cultures prepared fromthese models. The in vitro unit will also carry out studies of these models using live cell measurement ofcytosolic calcium levels and anatomical studies of receptor expression and localization. Important strengthsof this SNAPS Core include the expertise and knowledge of the faculty and staff, their long-term workingrelationships, and their commitment to neuroAIDS research.
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