Schizophrenia remains one of the most disabling diseases in medicine. Interventions research is crucial for improving the lives of individuals who are at risk for, or who have developed this illness. Pharmacotherapy, coupled with psychosocial and rehabilitative treatment, continues to be essential. Functional outcomes remain disappointing, positive symptoms persist in many patients, and cognitive dysfunction and negative symptoms continue to be less treatment responsive than positive symptoms. Relapse is the rule, to the extent that repeated episodes are assumed to characterize the typical course of illness. Adverse effects remain a challenge, but the focus has shifted from neuromotor to metabolic adverse effects. Early phase illness stands out as an area with a great need for intervention research, providing a rich opportunity for an ACISR. We define early phase as those at risk for or within the first 5 years following diagnosis. Maximizing treatment effectiveness in early phase illness could have a profound impact on future course. Treatments for early phase patients have been tested mainly in chronic patients;the study of factors that predict response is likely to be more informative, with fewer confounds, in early phase illness. The overall goal of the proposed ACISR is to enhance investigator initiated science by providing infrastructure support to maximize research opportunities in three populations: Individuals experiencing prodromal signs and symptoms of schizophrenia;early onset schizophrenia, and first episode schizophrenia.
The specific aims of our research efforts are to: 1) characterize the evolution of psychosis and identify targets for early intervention, 2) optimize interventions and outcomes in early phase illness, 3) assess, prevent, and minimize adverse effects of pharmacologic agents, 4) identify factors that predict treatment response. A key component of our proposed ACISR is to maintain and expand a research network consisting of non- academic, public and private community facilities, as well as local schools to enhance research opportunities and generalizability, as well as helping to improve levels of care in these programs. We believe that this ACISR would enable us to expand and extend our efforts in these valuable populations and to create a unique national resource. OPERATIONS CORE

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZMH1-DEA-J (01))
Program Officer
Vitiello, Benedetto
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Feinstein Institute for Medical Research
United States
Zip Code
McLaughlin, Danielle; Carrión, Ricardo E; Auther, Andrea M et al. (2016) Functional Capacity Assessed by the Map Task in Individuals at Clinical High-Risk for Psychosis. Schizophr Bull 42:1234-42
Schwehm, Andrew; Robinson, Delbert G; Gallego, Juan A et al. (2016) Age and Sex Effects on White Matter Tracts in Psychosis from Adolescence through Middle Adulthood. Neuropsychopharmacology 41:2473-80
Carrión, Ricardo E; Demmin, Docia; Auther, Andrea M et al. (2016) Duration of attenuated positive and negative symptoms in individuals at clinical high risk: Associations with risk of conversion to psychosis and functional outcome. J Psychiatr Res 81:95-101
Carrión, Ricardo E; Cornblatt, Barbara A; Burton, Cynthia Z et al. (2016) Personalized Prediction of Psychosis: External Validation of the NAPLS-2 Psychosis Risk Calculator With the EDIPPP Project. Am J Psychiatry 173:989-996
Prendergast, Daniel M; Ardekani, Babak; Ikuta, Toshikazu et al. (2015) Age and sex effects on corpus callosum morphology across the lifespan. Hum Brain Mapp 36:2691-702
Carrión, Ricardo E; Cornblatt, Barbara A; McLaughlin, Danielle et al. (2015) Contributions of early cortical processing and reading ability to functional status in individuals at clinical high risk for psychosis. Schizophr Res 164:1-7
Toteja, Nitin; Guvenek-Cokol, Perihan; Ikuta, Toshikazu et al. (2015) Age-associated alterations in corpus callosum white matter integrity in bipolar disorder assessed using probabilistic tractography. Bipolar Disord 17:381-91
Cornblatt, Barbara A; Carrión, Ricardo E; Auther, Andrea et al. (2015) Psychosis Prevention: A Modified Clinical High Risk Perspective From the Recognition and Prevention (RAP) Program. Am J Psychiatry 172:986-94
Carrión, R E; McLaughlin, D; Auther, A M et al. (2015) The impact of psychosis on the course of cognition: a prospective, nested case-control study in individuals at clinical high-risk for psychosis. Psychol Med 45:3341-54
Olvet, Doreen M; Carrión, Ricardo E; Auther, Andrea M et al. (2015) Self-awareness of functional impairment in individuals at clinical high-risk for psychosis. Early Interv Psychiatry 9:100-7

Showing the most recent 10 out of 76 publications