The University of Texas Health Science Center at San Antonio proposes to establish an Advanced Center for Interventions and/or Service Research to conduct research that will personalize community based treatment of bipolar disorders to improve outcomes. We will investigate interactions of cultural factors, adherence and engagement, behavioral domains and biological factors with outcomes, thereby providing a model that can transform current diagnostic and treatment paradigms for bipolar disorder. A major aim of this application is to better develop our understanding of bipolar disorder in the Hispanic American population, in particular the impact of acculturation on adherence to treatment programs. This program will train researchers to work more effectively with this largest U.S. minority population, particularity Mexican Americans who form the majority of Hispanics in the U.S. We will disseminate the knowledge and methodologies we develop to the larger U.S. Hispanic American community, as well as clinicians providing care for persons with bipolar disorder. The studies of the Center will enroll patients who are representative of the full spectrum of patients who receive care in community settings. These projects will contribute to development of more cost effective treatment regimens that are personalized to the characteristics of the patient and weigh tolerability as highly as efficacy. We will develop and promulgate study designs addressing sustained benefit and functional outcomes, sensitive assessments of the fundamental symptom domains in bipolar disorder, and statistical approaches that emphasize patient function. These efforts will be facilitated by our group of nationally recognized leaders in bipolar studies, an experienced scientific staff, the majority of whom are also Hispanic, and national leaders of research on diverse aspects of bipolar disorder. These efforts will equip us to serve as a national resource to advance the NIMH mission of reducing the burden of bipolar illness and improve outcomes through the efforts of research about treatments and their acceptability to patients, and broadly disseminate this research for the purposes of improving clinical care, public education and public health planning.

Public Health Relevance

Bipolar disorders start early in life and persist through it, and are one of the 10 major causes of disability in the world. This program of clinical research will personalize treatments to individual characteristics that can yield sustained good outcomes. These aims will be achieved by improving early, accurate diagnosis, tailoring drug and counseling to specific patient needs, recognizing and providing culturally competent care, with a particular emphasis in the Hispanic American population.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZMH1)
Program Officer
Rudorfer, Matthew V
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University of Texas Health Science Center
Schools of Medicine
San Antonio
United States
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Fries, Gabriel R; Colpo, Gabriela D; Monroy-Jaramillo, Nancy et al. (2017) Distinct lithium-induced gene expression effects in lymphoblastoid cell lines from patients with bipolar disorder. Eur Neuropsychopharmacol 27:1110-1119
Fang, Fang; Wang, Zuowei; Wu, Renrong et al. (2017) Is there a 'weight neutral' second-generation antipsychotic for bipolar disorder? Expert Rev Neurother 17:407-418
Tohen, Mauricio; Mintz, Jim; Bowden, Charles L (2016) Analysis of bipolar maintenance treatment with lithium versus olanzapine utilizing Multi-state Outcome Analysis of Treatments (MOAT). Bipolar Disord 18:282-7
Arnold, Jodi Gonzalez; Martinez, Cervando; Zavala, Juan et al. (2016) Investigating symptom domains of bipolar disorder for Spanish-speakers using the Bipolar Inventory of Symptoms Scale. J Affect Disord 205:239-244
Perlick, Deborah A; Berk, Lesley; Kaczynski, Richard et al. (2016) Caregiver burden as a predictor of depression among family and friends who provide care for persons with bipolar disorder. Bipolar Disord 18:183-91
Bowden, C L; Mintz, J; Tohen, M (2016) Multi-state outcome analysis of treatments (MOAT): application of a new approach to evaluate outcomes in longitudinal studies of bipolar disorder. Mol Psychiatry 21:237-42
Bowden, Charles L; Singh, Vivek (2016) The use of antidepressants in bipolar disorder patients with depression. Expert Opin Pharmacother 17:17-25
Gonzalez Arnold, Jodi; Salcedo, Stephanie; Ketter, Terrence A et al. (2015) An exploratory study of responses to low-dose lithium in African Americans and Hispanics. J Affect Disord 178:224-8
Bowden, Charles L (2015) Providing assessable information on effectiveness of maintenance treatments for bipolar disorder to psychiatrists and patients. Evid Based Ment Health 18:58
Singh, V; Bowden, C L; Gonzalez, J M et al. (2013) Discriminating primary clinical states in bipolar disorder with a comprehensive symptom scale. Acta Psychiatr Scand 127:145-52

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