The prevalence of mental health illness among patients with HIV is a significant public health issue. The translation of discoveries found at the bench to clinical practice (bench to bedside) is critical for advancements in diagnosing and therapeutic intervention to be made. This relationship, however, is not a one-way street, but bi-directional, where observations made in a clinical setting may also stimulate research at the bench. As such, it is important to develop a collaborative, multi-disciplinary community of clinicians and scientists to foster new discoveries with practical application in diagnosing and treating HIV+ persons with neuropsychological illness. To address this need, the Clinical and Behavioral Core will assist basic and clinical investigators wishing to include human subjects from a well-characterized cohort of HIV+ individuals in their studies, including those assessed for neuropsychological function. We will assist new and established investigators in the design and coordination of their studies, the preparation of required forms and approvals and data collection. To achieve this, the Clinical and Behavioral Core will have three primary functions: 1.) Provide the clinical cohort from the Temple Comprehensive HIV program with its infrastructure, operations management and regulatory oversight for clinical studies involving other CNACC cores or non-CNACC clinical collaborators, 2.) Systematically collect baseline and longitudinal neurocognitive, neurologic and psychiatric assessments on patients in Temple's HIV practice in collaboration with the Department of Psychiatry (for our revised application, we have included an expert neuropsychologist with HIV/AIDS neurocognitive testing and analysis experience, recently hired by Temple University Hospital (Dr. Nancy Minniti) and a consultant with internationally recognized expertise in neurocognitive testing, Dr. Kevin Robertson from the University of North Carolina.), and 3.) Develop and maintain a neurodatabase that will contain data from assessments in function #2, as well as relevant immunologic and virologic data from the Temple HIV clinical database and other studies conducted through CNACC.

Public Health Relevance

This core enables the integration of basic science investigations with clinical populations to further the aims of neuroscience translational research and expand opportunities for cross-disciplinary studies in epidemiology, public health and behavioral medicine. The core research activities foster the evaluation and application of novel targets and therapies in the management and care of HIV infected patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Center Core Grants (P30)
Project #
5P30MH092177-03
Application #
8477303
Study Section
Special Emphasis Panel (ZMH1-ERB-F)
Project Start
Project End
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$273,541
Indirect Cost
$94,756
Name
Temple University
Department
Type
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Mohseni Ahooyi, Taha; Shekarabi, Masoud; Decoppet, Emilie A et al. (2018) Network analysis of hippocampal neurons by microelectrode array in the presence of HIV-1 Tat and cocaine. J Cell Physiol 233:9299-9311
Tahrir, Farzaneh G; Shanmughapriya, Santhanam; Ahooyi, Taha Mohseni et al. (2018) Dysregulation of mitochondrial bioenergetics and quality control by HIV-1 Tat in cardiomyocytes. J Cell Physiol 233:748-758
Donadoni, Martina; Sariyer, Rahsan; Wollebo, Hassen et al. (2018) Viral tumor antigen expression is no longer required in radiation-resistant subpopulation of JCV induced mouse medulloblastoma cells. Genes Cancer 9:130-141
Cotto, Bianca; Natarajaseenivasan, Kalimuthusamy; Ferrero, Kimberly et al. (2018) Cocaine and HIV-1 Tat disrupt cholesterol homeostasis in astrocytes: Implications for HIV-associated neurocognitive disorders in cocaine user patients. Glia 66:889-902
Bella, Ramona; Kaminski, Rafal; Mancuso, Pietro et al. (2018) Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice. Mol Ther Nucleic Acids 12:275-282
Mohseni Ahooyi, Taha; Shekarabi, Masoud; Torkzaban, Bahareh et al. (2018) Dysregulation of Neuronal Cholesterol Homeostasis upon Exposure to HIV-1 Tat and Cocaine Revealed by RNA-Sequencing. Sci Rep 8:16300
Craigie, Michael; Cicalese, Stephanie; Sariyer, Ilker Kudret (2018) Neuroimmune Regulation of JC Virus by Intracellular and Extracellular Agnoprotein. J Neuroimmune Pharmacol 13:126-142
Mele, Anthony R; Marino, Jamie; Chen, Kenneth et al. (2018) Defining the molecular mechanisms of HIV-1 Tat secretion: PtdIns(4,5)P2 at the epicenter. Traffic :
Delcour, Maxime; Russier, Michaƫl; Castets, Francis et al. (2018) Early movement restriction leads to maladaptive plasticity in the sensorimotor cortex and to movement disorders. Sci Rep 8:16328
Cotto, Bianca; Li, Hongbo; Tuma, Ronald F et al. (2018) Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiol Dis 117:28-41

Showing the most recent 10 out of 124 publications