This Core takes advantage of existing successful EM and Confocal Imaging Cores and will be directed by the PI (Dr. Jackson) and the present co-Directors of the existing Confocal Facility (Drs. Hunter, Jacob, and Kauer). In addition, an expert outside consultant, Dr. Kent Keyser (UAB) will also aid in the oversight and maintenance of this Core. Funds have been recently obtained that will add multiphoton capability to the Confocal Imaging Core. The multiphoton capability will greatly increase the research capabilities and progress of the Neuroscience Faculty. The new Core will also make FRET based approaches accessible to the Neuroscience Investigators. A principal goal of this Core is to provide ongoing support for personnel and equipment upgrades to allow for non-prohibitive user fees. The current scheme for user fees predicts that the hourly rate for the Confocal Facility would increase to at least $65 per hour in the absence of the requested support. Further, the addition of 2-photon capability will place increased demand on the services of the current manager, Mr. McConnell. Thus, additional technical support personnel are required to take full advantage of existing capabilities. Additional space will be provided by the administration within new Neuroscience space for one microscope. Another microscope and the EM Facility will remain where they currently are as this space is adequate.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS047243-02
Application #
7554004
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Project Start
Project End
Budget Start
2004-08-01
Budget End
2005-07-31
Support Year
2
Fiscal Year
2004
Total Cost
$127,286
Indirect Cost
Name
Tufts University
Department
Type
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
You, Samantha; Fulga, Tudor A; Van Vactor, David et al. (2018) Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila. Genetics 208:1195-1207
Ahumada-Castro, Ulises; Silva-Pavez, Eduardo; Lovy, Alenka et al. (2018) MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells. Autophagy :1-4
Dickson, David A; Paulus, Jessica K; Mensah, Virginia et al. (2018) Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress. Transl Psychiatry 8:101
Xu, Jie; Bartolome, Christopher L; Low, Cho Shing et al. (2018) Genetic identification of leptin neural circuits in energy and glucose homeostases. Nature 556:505-509
Chen, Zhigang; Li, Wenlu; Qiu, Fuming et al. (2018) Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer. Theranostics 8:4447-4461
Melón, Laverne Camille; Hooper, Andrew; Yang, Xuzhong et al. (2018) Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice. Psychoneuroendocrinology 90:182-193
Kim, WonHee; Ma, Liang; Lomoio, Selene et al. (2018) BACE1 elevation engendered by GGA3 deletion increases ?-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener 13:6
Cai, Weikang; Xue, Chang; Sakaguchi, Masaji et al. (2018) Insulin regulates astrocyte gliotransmission and modulates behavior. J Clin Invest 128:2914-2926
Shaban, Lamyaa; Chen, Ying; Fasciano, Alyssa C et al. (2018) A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerobe 50:85-92
Hooper, Andrew; Paracha, Rumzah; Maguire, Jamie (2018) Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors. Epilepsy Behav 78:124-133

Showing the most recent 10 out of 216 publications