Abstract

and Relevance. Studies of animal behavior are necessary to characterize cardinal symptoms of disorders for which altered genetic expression and neurochemistry have been proposed. Comprehensive behavioral phenotyping, however, requires expertise and instrumentation beyond the financial and technical capabilities of most individual investigators. The mission of the ABC is to provide access to a state of the art behavioral assessment facility and expert services for assessing the behavioral effects of neuropharmacological or molecular genetic manipulations in order to identify therapeutic targets for treating CNS disorders. Since its inception in 2004, the ABC has served over 38 investigators within the neuroscience community. The ABC is a high impact resource; experiments accomplished using the ABC and its services have resulted in 13 publications and 29 NIH-funded grants. The ABC is emerging as a regional resource, serving neuroscientists within the Tufts community and drawing investigators from neighboring institutions.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS047243-12
Application #
8791714
Study Section
Special Emphasis Panel (ZNS1-SRB-R)
Project Start
Project End
Budget Start
2015-02-01
Budget End
2016-01-31
Support Year
12
Fiscal Year
2015
Total Cost
$127,360
Indirect Cost
$50,172

  Institution

Name
Tufts University
Department
Type
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

You, Samantha; Fulga, Tudor A; Van Vactor, David et al. (2018) Regulation of Circadian Behavior by Astroglial MicroRNAs in Drosophila. Genetics 208:1195-1207
Ahumada-Castro, Ulises; Silva-Pavez, Eduardo; Lovy, Alenka et al. (2018) MTOR-independent autophagy induced by interrupted endoplasmic reticulum-mitochondrial Ca2+ communication: a dead end in cancer cells. Autophagy :1-4
Dickson, David A; Paulus, Jessica K; Mensah, Virginia et al. (2018) Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress. Transl Psychiatry 8:101
Xu, Jie; Bartolome, Christopher L; Low, Cho Shing et al. (2018) Genetic identification of leptin neural circuits in energy and glucose homeostases. Nature 556:505-509
Chen, Zhigang; Li, Wenlu; Qiu, Fuming et al. (2018) Aspirin cooperates with p300 to activate the acetylation of H3K9 and promote FasL-mediated apoptosis of cancer stem-like cells in colorectal cancer. Theranostics 8:4447-4461
Melón, Laverne Camille; Hooper, Andrew; Yang, Xuzhong et al. (2018) Inability to suppress the stress-induced activation of the HPA axis during the peripartum period engenders deficits in postpartum behaviors in mice. Psychoneuroendocrinology 90:182-193
Kim, WonHee; Ma, Liang; Lomoio, Selene et al. (2018) BACE1 elevation engendered by GGA3 deletion increases ?-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice. Mol Neurodegener 13:6
Cai, Weikang; Xue, Chang; Sakaguchi, Masaji et al. (2018) Insulin regulates astrocyte gliotransmission and modulates behavior. J Clin Invest 128:2914-2926
Shaban, Lamyaa; Chen, Ying; Fasciano, Alyssa C et al. (2018) A 3D intestinal tissue model supports Clostridioides difficile germination, colonization, toxin production and epithelial damage. Anaerobe 50:85-92
Hooper, Andrew; Paracha, Rumzah; Maguire, Jamie (2018) Seizure-induced activation of the HPA axis increases seizure frequency and comorbid depression-like behaviors. Epilepsy Behav 78:124-133

Showing the most recent 10 out of 216 publications