This application requests continuing support for P30 Core Center grant focused on microscopy-basedBioimaging to support the needs of a large number of NINDS-funded investigators resident at VirginiaCommonwealth University. The previous application afforded the Principal Investigator the opportunity todevelop a contemporary bioimaging facility and target other federal and non-federal sources to allow for itscontinued expansion, together with the recruitment of a core director possessing recognized expertise in thefield of Bioimaging. The equipment, resources, staff and director, all of which were a direct outgrowth of thisfunded application have had significant impact on NINDS-sponsored and other NIH sponsored researchconducted at Virginia Commonwealth University. This competitive renewal asks for continued resources toboth maintain and update this highly productive core facility which as noted, serves the needs of NINDS andNeuroscience investigators throughout the Institution. As written, this application seeks support for thetechnical and administrative staff, instrumentation, and resources needed to support continued training,education and enhanced data analysis and archiving. The requested staff will maintain all instrumentationwhile providing continued training to the participating investigators, as well as their students and fellows.Additionally, the core staff will participate in select in vivo and in vitro preparations and procedures.Computer hardware and software are also requested to improve the quality of quantitative analysis of ourconfocal, multi-photon and electron microscopic imaging. Support is requested to maintain and upgradeexisting servers that are integral to data archiving and maintenance. Lastly, resources are requested tofacilitate live cell / live tissue imaging capabilities and enhance immunolocalization studies. Collectively, thiscompetitive renewal seeks to maintain our current momentum and build upon the resources provided in theprevious application. The goal is to continue to enhance the research productivity of our NINDS-fundedinvestigators, as well as their fellows and trainees via the provision of a cost effective, expertly staffed andwell managed state-of-the-art bioimaging core. Such a core is considered integral to the continued successof NINDS sponsored Neuroscience research at Virginia Commonwealth University.
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