This Is a competitive renewal of the Rocky Mountain Neurological Disorder Center (RMNOC) whose main goal Is to enhance and further research in areas of neurobiology targeted by the NINOS. The RMNO Center Core has established facilities that allow efficient generation and use of genetically-altered animals that display Interesting and Informative functional or behavioral phenotypes. Our existing cores have all been extremely successful and evolved to enable state-of-the-art approaches thereby allowing users to perform collaborative research in an efficient manner. Therefore, we propose to maintain the original cores with their original names, emphasizing that they will continue to evolve over the next five years, as described in the application (Cores A, 6, C, and 0). As before, the services provided by the four cores are not available elsewhere at the Anschutz Medical Campus. We propose four core facilities for the RMNO Center Core: Core A Microscopy Core (Bill Betz, Director) will provide advanced light and electron microscopy services. Core B Gene-Targeting/Viral Vector Core (Mark Dell'Acqua, Director) N design and construct vectors to generate gene-targeted and transgenic mice as well as viral targeting vectors. Core CZebrafish Transgenic Core (Angeles Ribera, Director)m provide services for maintaining and characterizing transgenic zebraflsh. Core D Machine Shop Core (Ulli Bayer, Director) will provide machine shop support services.
The major goal of the NINOS Is to reduce the burden of neurological disease. Meeting this goal requires fostering both basic and clinical neuroscience research. The Center Core fosters NINOS goals by enabling incorporation of cutting-edge genetic, molecular and imaging approaches into research that uses powerful vertebrate model systems (mice, rat and zebrafish).
|Tracy, Matthew E; Tesic, Vesna; Stamenic, Tamara Timic et al. (2018) CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology 135:343-354|
|Williams, Jason S; Hsu, Jessica Y; Rossi, Christy Cortez et al. (2018) Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration. Dev Biol :|
|Frank, Guido K W; DeGuzman, Marisa C; Shott, Megan E et al. (2018) Association of Brain Reward Learning Response With Harm Avoidance, Weight Gain, and Hypothalamic Effective Connectivity in Adolescent Anorexia Nervosa. JAMA Psychiatry 75:1071-1080|
|Peña, Brisa; Laughter, Melissa; Jett, Susan et al. (2018) Injectable Hydrogels for Cardiac Tissue Engineering. Macromol Biosci 18:e1800079|
|Olsavsky, Aviva K; Shott, Megan E; DeGuzman, Marisa C et al. (2018) Neural correlates of taste reward value across eating disorders. Psychiatry Res Neuroimaging :|
|Ramirez-Gordillo, Daniel; Ma, Ming; Restrepo, Diego (2018) Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation. Front Cell Neurosci 12:48|
|Gano, Lindsey B; Liang, Li-Ping; Ryan, Kristen et al. (2018) Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy. Free Radic Biol Med 123:116-124|
|Moreno, Rosa L; Williams, Kristina; Jones, Kenneth L et al. (2018) Investigation of Islet2a function in zebrafish embryos: Mutants and morphants differ in morphologic phenotypes and gene expression. PLoS One 13:e0199233|
|Woolfrey, Kevin M; O'Leary, Heather; Goodell, Dayton J et al. (2018) CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression. J Biol Chem 293:1551-1567|
|Ozbay, Baris N; Futia, Gregory L; Ma, Ming et al. (2018) Three dimensional two-photon brain imaging in freely moving mice using a miniature fiber coupled microscope with active axial-scanning. Sci Rep 8:8108|
Showing the most recent 10 out of 142 publications