Zebrafish Core C3.1 Rationale. Core C maintains wild type, transgenic and mutant zebrafish strains for RMNDC investigators. The unique developmental and optical imaging properties of the zebrafish embryo makes it an ideal model to address questions at the heart of the research programs RMNDC investigators. UCD NINDS researchers are internationally recognized and expert in the fields of neurophysiology, neurodevelopment and optical imaging. During the previous award period. Core C removed technical barriers for RMNDC investigators who were interested in using the model system (e.g., Betz, Caldwell, Clouthier, Niswander, Restrepo, Taylor, Williams) but did not have experience or means for maintaining lines. We propose three Specific Aims for Core C that will allow RMNDC members to take advantage of the zebrafish system for neurodevelopmental and behavioral studies. In addition to the 13 current Core C users, the facility will allow access to the zebrafish model to investigators who have not considered its use because of the pragmatic limitations associated with maintaining and breeding zebrafish. In particular, there has been growing interest in complementing rodent studies (e.g.. Core B) with ones done in zebrafish (e.g., Appel, Artinger, Barlow, Clouthier, Macklin, Niswander, Restrepo, Williams), and vice versa. The core will also be a resource for the larger scientific community because transgenic lines will be described on the RMNDC website and made available to the Zebrafish International Resource Center (ZIRC) by the time of the first publication.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
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National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
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University of Colorado Denver
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Tracy, Matthew E; Tesic, Vesna; Stamenic, Tamara Timic et al. (2018) CaV3.1 isoform of T-type calcium channels supports excitability of rat and mouse ventral tegmental area neurons. Neuropharmacology 135:343-354
Williams, Jason S; Hsu, Jessica Y; Rossi, Christy Cortez et al. (2018) Requirement of zebrafish pcdh10a and pcdh10b in melanocyte precursor migration. Dev Biol :
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Peña, Brisa; Laughter, Melissa; Jett, Susan et al. (2018) Injectable Hydrogels for Cardiac Tissue Engineering. Macromol Biosci 18:e1800079
Olsavsky, Aviva K; Shott, Megan E; DeGuzman, Marisa C et al. (2018) Neural correlates of taste reward value across eating disorders. Psychiatry Res Neuroimaging :
Ramirez-Gordillo, Daniel; Ma, Ming; Restrepo, Diego (2018) Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation. Front Cell Neurosci 12:48
Gano, Lindsey B; Liang, Li-Ping; Ryan, Kristen et al. (2018) Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy. Free Radic Biol Med 123:116-124
Moreno, Rosa L; Williams, Kristina; Jones, Kenneth L et al. (2018) Investigation of Islet2a function in zebrafish embryos: Mutants and morphants differ in morphologic phenotypes and gene expression. PLoS One 13:e0199233
Woolfrey, Kevin M; O'Leary, Heather; Goodell, Dayton J et al. (2018) CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression. J Biol Chem 293:1551-1567
Ozbay, Baris N; Futia, Gregory L; Ma, Ming et al. (2018) Three dimensional two-photon brain imaging in freely moving mice using a miniature fiber coupled microscope with active axial-scanning. Sci Rep 8:8108

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