Abstract

Core A ? Optogenetics and Neural Engineering: Project Summary (Abstract) The overall goal of the Optogenetics and Neural Engineering (ONE) Core is to enhance existing neuroscience research programs on the University of Colorado Anschutz Medical Campus (UC-AMC) by providing support for experiments and quantitative analysis. Specifically, the ONE Core will facilitate the adoption and optimization of optogenetic techniques in users' research by providing optical equipment and technical expertise (Aim 1), reducing the significant upfront costs required to leverage the advantages of optogenetics. Proof-of-principle for executing this Aim of the ONE Core is provided by the UC School of Medicine-supported Optogenetics Pilot Program, which has confirmed both the need for, and impact of, supporting optogenetic approaches at UC-AMC. In addition, the ONE Core will provide support for quantitative analysis and the development of experimental equipment (Aim 2). By achieving these Aims, the ONE Core will enhance a broad range of strong neuroscience research at UC-AMC consistent with the mission of the NINDS to obtain basic information about nervous system function and ultimately decrease the burden of neurological disease.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS048154-13
Application #
9402664
Study Section
Special Emphasis Panel (ZNS1)
Project Start
2004-09-15
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
13
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Olsavsky, Aviva K; Shott, Megan E; DeGuzman, Marisa C et al. (2018) Neural correlates of taste reward value across eating disorders. Psychiatry Res Neuroimaging :
Ramirez-Gordillo, Daniel; Ma, Ming; Restrepo, Diego (2018) Precision of Classification of Odorant Value by the Power of Olfactory Bulb Oscillations Is Altered by Optogenetic Silencing of Local Adrenergic Innervation. Front Cell Neurosci 12:48
Gano, Lindsey B; Liang, Li-Ping; Ryan, Kristen et al. (2018) Altered mitochondrial acetylation profiles in a kainic acid model of temporal lobe epilepsy. Free Radic Biol Med 123:116-124
Moreno, Rosa L; Williams, Kristina; Jones, Kenneth L et al. (2018) Investigation of Islet2a function in zebrafish embryos: Mutants and morphants differ in morphologic phenotypes and gene expression. PLoS One 13:e0199233
Woolfrey, Kevin M; O'Leary, Heather; Goodell, Dayton J et al. (2018) CaMKII regulates the depalmitoylation and synaptic removal of the scaffold protein AKAP79/150 to mediate structural long-term depression. J Biol Chem 293:1551-1567
Ozbay, Baris N; Futia, Gregory L; Ma, Ming et al. (2018) Three dimensional two-photon brain imaging in freely moving mice using a miniature fiber coupled microscope with active axial-scanning. Sci Rep 8:8108
Bourke, Ashley M; Bowen, Aaron B; Kennedy, Matthew J (2018) New approaches for solving old problems in neuronal protein trafficking. Mol Cell Neurosci 91:48-66
Gould, Elizabeth A; Busquet, Nicolas; Shepherd, Douglas et al. (2018) Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone. Elife 7:
Purkey, Alicia M; Woolfrey, Kevin M; Crosby, Kevin C et al. (2018) AKAP150 Palmitoylation Regulates Synaptic Incorporation of Ca2+-Permeable AMPA Receptors to Control LTP. Cell Rep 25:974-987.e4
Cook, Sarah G; Bourke, Ashley M; O'Leary, Heather et al. (2018) Analysis of the CaMKII? and ? splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep 8:5448

Showing the most recent 10 out of 142 publications