Since its establishment in 1998, the New York University Protein Analysis Facility has provided cutting edge mass spectrometry-based protein analysis to investigators at the New York University School of Medicine. Because of the expensive and sophisticated equipment and expertise required, it is impractical or impossible to perform these analyses in individual labs. As a result, demand for facility services has rapidly increased. The purpose of this grant is to provide funding to enable neuroscientists at NYU to take advantage of sophisticated and involved protein mass spectrometry and proteomics that would otherwise not be available to them, and guarantee them access to the technology. The proposed Protein Mass Spectrometry Core Facility for Neuroscience would enable NINDS- and other NIH funded neuroscientists at New York University to identify from one to many hundreds of proteins of interest, to characterize posttranslational modifications of these proteins such as phosphorylation, glycosylation, proteolysis and modification by lipids, to perform functional proteomics studies to identify the proteins involved in key signal transduction processes in neurons, and to characterize protein-protein interactions by surface plasmon resonance. Research areas that would greatly benefit from this core facility include nerve growth and regeneration, neuromuscular junction formation, cancer metastasis, amyloidosis and cerebral hemorrhagic stroke, axon guidance, axon domain assembly, lesion induced synaptic plasticity, potassium channel function, Alzheimer's and other amyloid diseases, brain development, opioid addiction, aging, and neurotransmitter receptor trafficking.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS050276-03
Application #
7236060
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Program Officer
Miller, Thomas
Project Start
2005-07-01
Project End
2010-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
3
Fiscal Year
2007
Total Cost
$767,490
Indirect Cost
Name
New York University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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