Since its establishment in 2005, the New York University Protein Mass Spectrometry Core Facility for neuroscience has provided cutting edge mass spectrometry-based protein analysis to molecular neuroscientists at the New York University School of Medicine. The purpose of this grant is to provide continued funding to enable neuroscientists at NYU to take advantage of sophisticated and involved protein mass spectrometry and proteomics that would otherwise not be available to them, and guarantee them access to the technology. The proposed Protein Mass Spectrometry Core Facility for Neuroscience would enable NINDS- and other NIH- funded neuroscientists at New York University to identify from one to thousands of proteins of interest, to characterize posttranslational modifications of these proteins such as phosphorylation, glycosylation, proteolysis and modification by lipids, to perform functional proteomics studies to identify the proteins involved in key signal transduction processes in neurons, to characterize protein-protein interactions by surface plasmon resonance and to perform automated RNAi experiments. Research areas that would greatly benefit from this core facility include nerve growth and regeneration, neuromuscular junction formation, cancer metastasis, axon guidance, axon domain assembly, lesion induced synaptic plasticity, potassium channel function, Alzheimer's and other amyloid diseases, brain development, aging, brain cancer, and neurotransmitter receptor trafficking.

Public Health Relevance

The NYU Mass Spectrometry Core Facility for Neuroscience ensures that neuroscientists have access to cutting edge mass spectrometry technology to enable their basic research in such key areas as nerve growth and regeneration, neuromuscular disorders, cerebral hemorrhagic stroke, nervous system development, synaptic plasticity, affective disorders such as depression, Alzheimer's and other amyloid diseases, and aging.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS050276-09
Application #
8733763
Study Section
National Institute of Neurological Disorders and Stroke Initial Review Group (NSD)
Program Officer
Talley, Edmund M
Project Start
2004-12-01
Project End
2016-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
9
Fiscal Year
2014
Total Cost
$705,683
Indirect Cost
$288,119
Name
New York University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
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