MRS in conjunction with [13]C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. However the application of MRS by neuroscientists is hindered by a steep learning curve as well as technological barriers, which include the need for significant resource and expertise centralization. In the last cycle. Core 2 implemented and provided support for the use of a wide range of state-of-the-art MRS methods and combined studies of MRS with MRI (Core 1) and neurophysiological recordings (Core 3) in conjunction with project-specific data analysis (Core 4). Through new user recruitment as well as support and training. Core 2 now supports the work of 7 qualifying Pis funded by NINDS who along with 16 other NIH-funded Pis use multinuclear MRS to address fundamental questions in basic and clinical neuroscience. The impact of Core 2 is further shown by support of work in 26 NIH grants and 3 new research initiatives that led to ROI grants, training of 5 neuroscientists in the use of MRS methods, and contributing to 50 papers that led to 604 citations (for Core 2 alone this represents 50% of the total citations for 106 papers for al| Cores). For the next cycle, we will continue to implement, maintain, and support innovative multinuclear MRS methods for Core 2 users, support new research initiatives, train and provide mentorship for neuroscience Pis and their staff for Core 2 usage, integrate synergistic use of MR/neurophysiological measurements and project-specific data analysis, implement new Core 2 methods to support neuroscience Pis, and track Core 2 activities and disseminate/share resources to NIH community. The newly implemented applications will include a variety of multinuclear MRS methods for high-resolution metabolic imaging and RF induced heat deposition measurements. The overall goal of Core 2 is to enhance NINDS- and NIH-funded research.

Public Health Relevance

Magnetic resonance spectroscopy (MRS) in conjunction with [13]C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. The application of MRS by neuroscientists is obstructed by significant technological challenges requiring resource and expertise centralization. Core 2 will support and develop spectroscopic neurolmaging to advance NIH supported projects of direct relevance to public health, and consistent with the NINDS mission.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS052519-06A1
Application #
8732256
Study Section
Special Emphasis Panel (ZNS1-SRB-B (38))
Project Start
Project End
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
6
Fiscal Year
2014
Total Cost
$187,960
Indirect Cost
$75,071
Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
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