MRS in conjunction with [13]C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. However the application of MRS by neuroscientists is hindered by a steep learning curve as well as technological barriers, which include the need for significant resource and expertise centralization. In the last cycle. Core 2 implemented and provided support for the use of a wide range of state-of-the-art MRS methods and combined studies of MRS with MRI (Core 1) and neurophysiological recordings (Core 3) in conjunction with project-specific data analysis (Core 4). Through new user recruitment as well as support and training. Core 2 now supports the work of 7 qualifying Pis funded by NINDS who along with 16 other NIH-funded Pis use multinuclear MRS to address fundamental questions in basic and clinical neuroscience. The impact of Core 2 is further shown by support of work in 26 NIH grants and 3 new research initiatives that led to ROI grants, training of 5 neuroscientists in the use of MRS methods, and contributing to 50 papers that led to 604 citations (for Core 2 alone this represents 50% of the total citations for 106 papers for al| Cores). For the next cycle, we will continue to implement, maintain, and support innovative multinuclear MRS methods for Core 2 users, support new research initiatives, train and provide mentorship for neuroscience Pis and their staff for Core 2 usage, integrate synergistic use of MR/neurophysiological measurements and project-specific data analysis, implement new Core 2 methods to support neuroscience Pis, and track Core 2 activities and disseminate/share resources to NIH community. The newly implemented applications will include a variety of multinuclear MRS methods for high-resolution metabolic imaging and RF induced heat deposition measurements. The overall goal of Core 2 is to enhance NINDS- and NIH-funded research.

Public Health Relevance

Magnetic resonance spectroscopy (MRS) in conjunction with [13]C isotopic labeled substrates is the only noninvasive method of brain imaging for cell-specific energy and neurotransmitter metabolism. The application of MRS by neuroscientists is obstructed by significant technological challenges requiring resource and expertise centralization. Core 2 will support and develop spectroscopic neurolmaging to advance NIH supported projects of direct relevance to public health, and consistent with the NINDS mission.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1-SRB-B (38))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Yale University
New Haven
United States
Zip Code
Thompson, Garth J; Sanganahalli, Basavaraju G; Baker, Keeley L et al. (2018) Spontaneous activity forms a foundation for odor-evoked activation maps in the rat olfactory bulb. Neuroimage 172:586-596
Yu, Yuguo; Herman, Peter; Rothman, Douglas L et al. (2018) Evaluating the gray and white matter energy budgets of human brain function. J Cereb Blood Flow Metab 38:1339-1353
Johnson, Matthew B; Sun, Xingshen; Kodani, Andrew et al. (2018) Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size. Nature 556:370-375
Johnson, Frances K; Delpech, Jean-Christophe; Thompson, Garth J et al. (2018) Amygdala hyper-connectivity in a mouse model of unpredictable early life stress. Transl Psychiatry 8:49
Mortensen, Kristian N; Gjedde, Albert; Thompson, Garth J et al. (2018) Impact of Global Mean Normalization on Regional Glucose Metabolism in the Human Brain. Neural Plast 2018:6120925
Thompson, Garth J (2018) Neural and metabolic basis of dynamic resting state fMRI. Neuroimage 180:448-462
Benveniste, Helene; Dienel, Gerald; Jacob, Zvi et al. (2018) Trajectories of Brain Lactate and Re-visited Oxygen-Glucose Index Calculations Do Not Support Elevated Non-oxidative Metabolism of Glucose Across Childhood. Front Neurosci 12:631
de Graaf, Robin A; De Feyter, Henk M; Brown, Peter B et al. (2017) Detection of cerebral NAD+ in humans at 7T. Magn Reson Med 78:828-835
Prinsen, Hetty; de Graaf, Robin A; Mason, Graeme F et al. (2017) Reproducibility measurement of glutathione, GABA, and glutamate: Towards in vivo neurochemical profiling of multiple sclerosis with MR spectroscopy at 7T. J Magn Reson Imaging 45:187-198
Kaneko, Gen; Sanganahalli, Basavaraju G; Groman, Stephanie M et al. (2017) Hypofrontality and Posterior Hyperactivity in Early Schizophrenia: Imaging and Behavior in a Preclinical Model. Biol Psychiatry 81:503-513

Showing the most recent 10 out of 149 publications