The overall goal of this inter-institutional grant Is to foster new interdisciplinary collaborations among neuroscientists in La Jolla institutions by allowing access to scientific cores to which they were previously denied or had little access, and by creating new cores to promote state-of-the-art technology. To accomplish this goal, we have chosen among the very best existing core facilities, and have chosen top scientists to run new cores at the institutions supporting neuroscientists on the La Jolla Torrey Pines Mesa, composed of the Burnham Institute for Medical Research (BIMR), The Salk Institute, The Scripps Research Institute (TSRI), and the University of California, San Diego (UCSD). These institutions share one of the top-rated neuro- science graduate programs in the country and have committed considerable institutional funds towards these cores. This work is aimed at developing new treatments for neurological disorders.
Specific Aims i nclude: 1. To obtain Core support for Neuroscientists in La Jolla to enable collaborative research in Systems Neurobiology. Examples of Cores for this discipline are Behavioral testing, Electrophysiology, Neuropathology, Stem Cells, Bioinformatics/Systems Biology, Viral Vectors/siRNA, and Cell Imaging/Histology. 2. To obtain Core support for Neuroscientists to enable collaborative Developmental Neurobiology research. Examples of Cores for this discipline are Electrophysiology, Cell/Molecular Imaging, Stem Cells, Proteomics, and Viral Vectors-siRNA Libraries. 3. To obtain Core support for Neuroscientists studying Neurodegenerative Disorders and developing Neuroprotective Therapies. Cores to enable collaboration in this discipline include Proteomics, Structural Biology-crystallography, High-throughput Cell Analysis, Chemical Library Screening, Behavioral testing, Gene Analysis/cDNA Microarrays, Bioinformatics, Neuropathology, Viral Vectors- siRNA, and Stem Cells. 4. To obtain Core support for Neuroscientists working the area of Stem Cells and Regenerative Medicine. Cores needed for collaborative work in this area include Stem Cells, Proteomics, Gene Analysis/cDNA Microarrays, Bioinformatics, Neuropathology, Electrophysiology, High-throughput Cell Analysis Chemical Screening, and Behavioral testing.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS057096-03
Application #
7680184
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2008-09-01
Budget End
2009-08-31
Support Year
3
Fiscal Year
2008
Total Cost
$57,495
Indirect Cost
Name
Sanford-Burnham Medical Research Institute
Department
Type
DUNS #
020520466
City
La Jolla
State
CA
Country
United States
Zip Code
92037
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Hoefer, Melanie M; Sanchez, Ana B; Maung, Ricky et al. (2015) Combination of methamphetamine and HIV-1 gp120 causes distinct long-term alterations of behavior, gene expression, and injury in the central nervous system. Exp Neurol 263:221-34
Valera, Elvira; Mante, Michael; Anderson, Scott et al. (2015) Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson's disease. J Neuroinflammation 12:93

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