In this application for an NINDS Center Core Grant, we seek support for a Neurotransgenic corelaboratory at Duke University. This core provides powerful tools for studying the nervous system,where the vast diversity of cell types and synaptic connections require tools that exceed those neededto study simpler, more homogenous tissues. This core will support individual neuroscience researchprojects by providing necessary resources and performing required services that would be difficult orimpractical to provide in individual labs. Institutional commitments of space and seed funds forequipment and salaries have already been obtained and have enabled the creation of this core withinthe past two years, the understanding being that extramural support would be obtained for theircontinued support. This core will enrich the effectiveness of ongoing NINDS-supported research atDuke, promote new directions for both basic and translational neuroscience research, and foster acooperative and interactive research environment through which multidisciplinary approaches toneuroscience problems and joint research efforts will be stimulated. Moreover, this provides acost-effective way for investigators to exploit cutting-edge, specialized technologies that would bedifficult to setup or justify for an individual laboratory. This core has been developed in partnership withother administrative units within Duke University including the Cancer Center. This core will beutilized by neuroscientists residing in multiple departments, thereby fostering a cooperative andinteractive research environment. This core represents a substantial infrastructure support for geneticanalysis in support of the neurosciences.