Abstract

The analysis and visualization of high field magnetic resonance imaging (MRI) and spectroscopy (MRS) data require cutting-edge computational resources and expertise, because of their increasing size and complexity. Although these advances will undoubtedly improve our understanding of brain development, aging and disorders, it can also be a significant barrier for investigators. Therefore, the overall goal of this core is to provide unique and easily accessible processing resources for human and animal neuroimaging research, which will empower researchers to efficiently produce state-of-the-art results, and generate high-quality images from CMRR's high and ultrahigh field MR scanners.
Aim 1 : To provide MRI data reconstruction and pre-processing expertise and tools, including parallel imaging, artifacts and distortion correction.
Aim 2 : To provide expertise and computational resources for MRI data analysis, including registration, segmentation, diffusion models fitting (tensor, crossing fibers models, microstructure), tractography, and fMRI statistical analysis.
Aim 3 : To provide quantitative imaging analysis capabilities, including generating quantitative brain maps of relaxation times.
Aim 4 : To provide processing and metabolite quantification capabilities for MRS.
Aim 5 : To provide data storage, organization and visualization capabilities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
2P30NS076408-06
Application #
9432739
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2017-09-01
Budget End
2018-08-31
Support Year
6
Fiscal Year
2017
Total Cost
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Friedrich, Jillian; Kordasiewicz, Holly B; O'Callaghan, Brennon et al. (2018) Antisense oligonucleotide-mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles. JCI Insight 3:
Chu, Shu-Hsien; Parhi, Keshab K; Lenglet, Christophe (2018) Function-specific and Enhanced Brain Structural Connectivity Mapping via Joint Modeling of Diffusion and Functional MRI. Sci Rep 8:4741
Adanyeguh, Isaac M; Monin, Marie-Lorraine; Rinaldi, Daisy et al. (2018) Expanded neurochemical profile in the early stage of Huntington disease using proton magnetic resonance spectroscopy. NMR Biomed 31:
Wilson, Sylia; Malone, Stephen M; Hunt, Ruskin H et al. (2018) Problematic alcohol use and hippocampal volume in a female sample: disentangling cause from consequence using a co-twin control study design. Psychol Med 48:1673-1684
Gulban, Omer F; De Martino, Federico; Vu, An T et al. (2018) Cortical fibers orientation mapping using in-vivo whole brain 7?T diffusion MRI. Neuroimage 178:104-118
Duchin, Yuval; Shamir, Reuben R; Patriat, Remi et al. (2018) Patient-specific anatomical model for deep brain stimulation based on 7 Tesla MRI. PLoS One 13:e0201469
Coles, Lisa D; Tuite, Paul J; Öz, Gülin et al. (2018) Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress. J Clin Pharmacol 58:158-167
Herzberg, Max P; Hodel, Amanda S; Cowell, Raquel A et al. (2018) Risk taking, decision-making, and brain volume in youth adopted internationally from institutional care. Neuropsychologia 119:262-270
Milham, Michael P; Ai, Lei; Koo, Bonhwang et al. (2018) An Open Resource for Non-human Primate Imaging. Neuron 100:61-74.e2
Patriat, Rémi; Cooper, Scott E; Duchin, Yuval et al. (2018) Individualized tractography-based parcellation of the globus pallidus pars interna using 7T MRI in movement disorder patients prior to DBS surgery. Neuroimage 178:198-209

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