Although MR techniques offer enormous potential for non-invasive in-vivo whole brain measurements, the interpretation of the measurements can be greatly enhanced when combined with classical neuroscience techniques. For example, although MR is particularly well suited for population level studies of neuronal chemistry or activity, its temporal resolution is often limited by hemodynamic factors. By combining high temporal resolution electrophysiology, such as provided by extracellular or EEG electrodes, with MR measurements, a more complete picture of brain metabolism and function is possible. One traditional challenge for such multimodal investigations is the high barrier to entry that neuroscience investigators face in trying to state-of-the-art MR techniques. The purpose of this core is to reduce this barrier to entry by encouraging and supporting the integration of the cutting-edge MR methods available at the CMRR with traditional neuroscience methodologies. This methodologies include behavioral measurements, electrophysiology, histochemistry, optical imaging, and tract tracing. Because of the success of the core in supporting a variety of such projects, as is documented in our Usage Tables, we propose to continue our efforts through human and equipment resources to promote the incorporation of MR techniques, and to assist in the design and implementation of multimodal

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Center Core Grants (P30)
Project #
5P30NS076408-09
Application #
10005500
Study Section
Special Emphasis Panel (ZNS1)
Project Start
Project End
Budget Start
2020-06-01
Budget End
2021-05-31
Support Year
9
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Coles, Lisa D; Tuite, Paul J; Öz, Gülin et al. (2018) Repeated-Dose Oral N-Acetylcysteine in Parkinson's Disease: Pharmacokinetics and Effect on Brain Glutathione and Oxidative Stress. J Clin Pharmacol 58:158-167
Herzberg, Max P; Hodel, Amanda S; Cowell, Raquel A et al. (2018) Risk taking, decision-making, and brain volume in youth adopted internationally from institutional care. Neuropsychologia 119:262-270
Milham, Michael P; Ai, Lei; Koo, Bonhwang et al. (2018) An Open Resource for Non-human Primate Imaging. Neuron 100:61-74.e2
Patriat, Rémi; Cooper, Scott E; Duchin, Yuval et al. (2018) Individualized tractography-based parcellation of the globus pallidus pars interna using 7T MRI in movement disorder patients prior to DBS surgery. Neuroimage 178:198-209
Park, Young Woo; Deelchand, Dinesh K; Joers, James M et al. (2018) AutoVOI: real-time automatic prescription of volume-of-interest for single voxel spectroscopy. Magn Reson Med 80:1787-1798
Marja?ska, Ma?gorzata; Deelchand, Dinesh K; Hodges, James S et al. (2018) Altered macromolecular pattern and content in the aging human brain. NMR Biomed 31:
U?urbil, Kamil (2018) Imaging at ultrahigh magnetic fields: History, challenges, and solutions. Neuroimage 168:7-32
Peña, Edgar; Zhang, Simeng; Patriat, Remi et al. (2018) Multi-objective particle swarm optimization for postoperative deep brain stimulation targeting of subthalamic nucleus pathways. J Neural Eng 15:066020
Wu, Xiaoping; Auerbach, Edward J; Vu, An T et al. (2018) High-resolution whole-brain diffusion MRI at 7T using radiofrequency parallel transmission. Magn Reson Med 80:1857-1870
Moerel, Michelle; De Martino, Federico; U?urbil, Kâmil et al. (2018) Evaluating the Columnar Stability of Acoustic Processing in the Human Auditory Cortex. J Neurosci 38:7822-7832

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