The Caenorhabditis Genetics Center (CGC) is the sole comprehensive repository and distribution center for the nematode Caenorhabditis elegans, a premier model organism for biomedical research studies. The overall objective of this animal resource is to promote research on C. elegans by acquiring, maintaining, and distributing genetically characterized nematode stocks. Researchers throughout the world use genetic stocks obtained from the CGC in diverse basic and applied research endeavors, as well as for hand-on teaching of experimental science. Studies using this premier model organism have led to fundamental insights into basic biological mechanisms, including the genetic basis of programmed cell death, the discovery of microRNAs, and the mechanism of RNA interference in animals. The nematode has also proved important for understanding mechanisms of cancer progression and other diseases including Alzheimer's and Parkinson's, as well as for revealing basic mechanisms underlying human development. In addition, C. elegans serves as a key model for illuminating our understanding of parasitic nematodes with relevance to human and livestock health. As the only general stock center for C. elegans, the CGC is an extremely important international research resource, supporting research in these diverse areas and educational endeavors. The CGC provides more than 30,000 strains are distributed per year to thousands of laboratories; with a collection of over 19,000 unique strains, still expanding in proportion to the growth of the field, the CGC not only facilitates research, but also ensures that valuable strains are preserved. The CGC distributes strains upon request through an on-line ordering system. A scheme of user fees helps to defray costs and support CGC activities. The CGC also includes a research component aimed at enhancing the CGC collection. Our close monitoring of user needs, ties with the C. elegans community, and focus on genetic tools has given us a unique perspective in devising a research component.
Two aims will be pursued, one focused on expanding the genetic tool-kit by generating intrachromosomal inversions for use as crossover suppressors. The other aim is to complete the collection of null mutations in microRNA genes.

Public Health Relevance

?Overall The Caenorhabditis Genetics Center (CGC) is the sole general international repository and distribution center for the nematode C. elegans. Researchers throughout the world make important discoveries in diverse areas of biology, many with relevance to human health, aging and disease, using this premier model organism and strains provided by the CGC. A small research component is designed to enhance the collection of C. elegans mutants and genetic tools available to the research community.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
5P40OD010440-10
Application #
10111580
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Zou, Sige
Project Start
2012-09-01
Project End
2022-02-28
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
10
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Genetics
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Ranawade, Ayush; Mallick, Avijit; Gupta, Bhagwati P (2018) PRY-1/Axin signaling regulates lipid metabolism in Caenorhabditis elegans. PLoS One 13:e0206540
He, Baoshen; Zhang, Jingjing; Wang, Yanli et al. (2018) Identification of cytochrome b5 CYTB-5.1 and CYTB-5.2 in C. elegans; evidence for differential regulation of SCD. Biochim Biophys Acta Mol Cell Biol Lipids 1863:235-246
White, Corin V; Herman, Michael A (2018) Transcriptomic, Functional, and Network Analyses Reveal Novel Genes Involved in the Interaction Between Caenorhabditis elegans and Stenotrophomonas maltophilia. Front Cell Infect Microbiol 8:266
Mazzochette, E A; Nekimken, A L; Loizeau, F et al. (2018) The tactile receptive fields of freely moving Caenorhabditis elegans nematodes. Integr Biol (Camb) 10:450-463
Seo, Yonghak; Kingsley, Samuel; Walker, Griffin et al. (2018) Metabolic shift from glycogen to trehalose promotes lifespan and healthspan in Caenorhabditis elegans. Proc Natl Acad Sci U S A 115:E2791-E2800
Kim, Sungjin; Sieburth, Derek (2018) Sphingosine Kinase Regulates Neuropeptide Secretion During the Oxidative Stress-Response Through Intertissue Signaling. J Neurosci 38:8160-8176
Ni, Julie Zhouli; Kalinava, Natallia; Mendoza, Sofia Galindo et al. (2018) The spatial and temporal dynamics of nuclear RNAi-targeted retrotransposon transcripts in Caenorhabditis elegans. Development 145:
Lanzo, Ambra; Safratowich, Bryan D; Kudumala, Sirisha R et al. (2018) Silencing of Syntaxin 1A in the Dopaminergic Neurons Decreases the Activity of the Dopamine Transporter and Prevents Amphetamine-Induced Behaviors in C. elegans. Front Physiol 9:576
Partridge, Frederick A; Forman, Ruth; Willis, Nicky J et al. (2018) 2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm. PLoS Negl Trop Dis 12:e0006487
Song, Myungchul; Song, Kyunghee; Kim, Sunghee et al. (2018) Caenorhabditis elegans BRICHOS Domain-Containing Protein C09F5.1 Maintains Thermotolerance and Decreases Cytotoxicity of A?42 by Activating the UPR. Genes (Basel) 9:

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