The overall goal of this proposal is to continue and expand the functions and capabilities of the Rat Resource and Research Center (RRRC) to provide biomedical investigators with the rat models, ES cells, related reagents and protocols they require for their research. In the last two years the biomedical community has developed several technologies to make targeted mutations (e.g., knock-outs and knock-ins) in rats. As a result the number of genetically engineered rat models and the number of investigators using rat models for biomedical research is likely to increase dramatically. The RRRC provides a unique repository service to the biomedical community for importing, storing and distributing a vast number of rat strains;as well as performing research that improves the function of the Resource Center. In addition to the animal repository, cryostorage, and distribution functions, the RRRC proposes to expand its function to assist investigators in the use of new rat gene targeting technologies and the unique challenges associated with these. The RRRC will do this by providing protocols for targeting and ES cell culture along with technical training in rat gene targeting. By expanding our services, the RRRC will serve as a much-needed resource for biomedical research investigators using rats in biomedical research.
The overall goal of this proposal is to continue and expand the functions and capabilities of the Rat Resource and Research Center (RRRC) to provide biomedical investigators with the rat models, ES cells, related reagents and protocols they require for their research.
|Weishaupt, Nina; Liu, Qingfan; Shin, Sheojung et al. (2018) APP21 transgenic rats develop age-dependent cognitive impairment and microglia accumulation within white matter tracts. J Neuroinflammation 15:241|
|Klakotskaia, Diana; Agca, Cansu; Richardson, Rachel A et al. (2018) Memory deficiency, cerebral amyloid angiopathy, and amyloid-? plaques in APP+PS1 double transgenic rat model of Alzheimer's disease. PLoS One 13:e0195469|
|Jones, Jade E; Busi, Susheel Bhanu; Mitchem, Jonathan B et al. (2018) Evaluation of a Tumor-Targeting, Near-Infrared Fluorescent Peptide for Early Detection and Endoscopic Resection of Polyps in a Rat Model of Colorectal Cancer. Mol Imaging 17:1536012118790065|
|Kelm, Natia Q; Beare, Jason E; Yuan, Fangping et al. (2018) Adipose-derived cells improve left ventricular diastolic function and increase microvascular perfusion in advanced age. PLoS One 13:e0202934|
|Ellegaard, Maria; Agca, Cansu; Petersen, Solveig et al. (2017) Bone turnover is altered in transgenic rats overexpressing the P2Y2 purinergic receptor. Purinergic Signal 13:545-557|
|Shimoyama, Mary; Smith, Jennifer R; Bryda, Elizabeth et al. (2017) Rat Genome and Model Resources. ILAR J 58:42-58|
|Ma, Man Chun John; Pettus, Janette M; Jakoubek, Jessica A et al. (2017) Contribution of independent and pleiotropic genetic effects in the metabolic syndrome in a hypertensive rat. PLoS One 12:e0182650|
|Mamad, Omar; Stumpp, Lars; McNamara, Harold M et al. (2017) Place field assembly distribution encodes preferred locations. PLoS Biol 15:e2002365|
|Li, Shuping; Lan, He; Men, Hongsheng et al. (2016) Derivation of Transgene-Free Rat Induced Pluripotent Stem Cells Approximating the Quality of Embryonic Stem Cells. Stem Cells Transl Med :|
|Hansen, Sarah A; Hart, Marcia L; Busi, Susheel et al. (2016) Fischer-344 Tp53-knockout rats exhibit a high rate of bone and brain neoplasia with frequent metastasis. Dis Model Mech 9:1139-1146|
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