This grant will provide continued NIH support to maintain the Caribbean Primate Research Center (CPRC). The CPRC consists of four integrated facilities: (1) Cayo Santiago, a unique free-ranging island colony of Indian-origin rhesus monkeys (Macaca mulatta);(2) the Sabana Seca Field Station, the CPRC's headquarters located 10 miles outside of San Juan, that houses rhesus monkeys derived from the Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals;(3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan;and (4) the Laboratory of Primate Morphology and Genetics (LPMG), which is also located on the MSC, and houses the CPRC Skeletal Collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology &Genetics. Funds are requested in this application only to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects across the United States. This core grant will also allow CPRC to seek additional support to launch collaborative research projects with mainland and international investigators. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy Indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.

Public Health Relevance

(provided by applicant): The CPRC continues to be a platform that supports numerous PHS-sponsored research projects throughout USA. The Center provides Indian-origin rhesus monkeys which serve as models for the development of effective treatments against human diseases. With the needed NCRR support to this grant, the CPRC will continue to be one of the largest nationwide providers of SPF and of conventional rhesus monkeys required for AIDS and for other biomedical research projects and a valuable research resource needed for behavioral and biomedical studies.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
8P40OD012217-25
Application #
8210834
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Program Officer
Contreras, Miguel A
Project Start
1987-04-15
Project End
2015-11-30
Budget Start
2011-12-01
Budget End
2012-11-30
Support Year
25
Fiscal Year
2012
Total Cost
$2,222,603
Indirect Cost
$739,534
Name
University of Puerto Rico Med Sciences
Department
Type
Other Domestic Higher Education
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
Larson, Sam M; Ruiz-Lambides, Angelina; Platt, Michael L et al. (2018) Social network dynamics precede a mass eviction in group-living rhesus macaques. Anim Behav 136:185-193
Sariol, Carlos A; Nogueira, Mauricio L; Vasilakis, Nikos (2018) A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease? Trends Microbiol 26:186-190
Madlon-Kay, Seth; Montague, Michael J; Brent, Lauren J N et al. (2018) Weak effects of common genetic variation in oxytocin and vasopressin receptor genes on rhesus macaque social behavior. Am J Primatol 80:e22873
Kanthaswamy, Sreetharan; Oldt, Robert F; Ng, Jillian et al. (2018) Determination of major histocompatibility class I and class II genetic composition of the Caribbean Primate Center specific pathogen-free rhesus macaque (Macaca mulatta) colony based on massively parallel sequencing. J Med Primatol 47:379-387
Hardin, Anna M (2018) Genetic contributions to dental dimensions in brown-mantled tamarins (Saguinus fuscicollis) and rhesus macaques (Macaca mulatta). Am J Phys Anthropol :
Fernández, Peter J; Mongle, Carrie S; Leakey, Louise et al. (2018) Evolution and function of the hominin forefoot. Proc Natl Acad Sci U S A 115:8746-8751
Al-Attar, Ahmad; Alimova, Yelena; Kirakodu, Sreenatha et al. (2018) Activation of Notch-1 in oral epithelial cells by P. gingivalis triggers the expression of the antimicrobial protein PLA2-IIA. Mucosal Immunol 11:1047-1059
Ebersole, Jeffrey L; Novak, Michael John; Orraca, Luis et al. (2018) Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. Immunology 154:452-464
Gonzalez, O A; Kirakodu, S; Novak, M J et al. (2018) Comparative analysis of microbial sensing molecules in mucosal tissues with aging. Immunobiology 223:279-287
Ebersole, J L; Dawson 3rd, D A; Emecen Huja, P et al. (2018) Age and Periodontal Health - Immunological View. Curr Oral Health Rep 5:229-241

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