The major goal of this application is to improve and maintain the Caribbean Primate Research Center's (CPRC) unique research resources through support of operations, administration, veterinary care and research. The CPRC consists of four integrated facilities: (1) Cayo Santiago Field Station, the most valuable of the CPRC research resources that holds a colony of free-ranging rhesus brought from India to Cayo Santiago (CS) in 1938.; (2) the Sabana Seca Field Station, the CPRC's head quarters located 10 miles outside of San Juan that houses rhesus monkeys derived from Cayo Santiago colony in various outdoor configurations for biomedical and behavioral studies that are not feasible on free-ranging animals; (3) the Laboratory of Virology and Genetics (LVG), located on the Medical Sciences Campus (MSC), in San Juan which support several research initiatives using rhesus monkeys as a model; and (4) the Laboratory of Primate Morphology (LPM), which is also located on the MSC, and houses the CPRC skeletal collections, unique assemblages of nonhuman primate skeletons for genetic, developmental, pathological and anatomical research. As described in this proposal, CPRC is organized into four complementary and integrated divisions: Primate Resources, Virology and Genetics, Behavior and Neurosciences, and Primate Morphology. Funds are requested in this application to maintain CPRC basic infrastructure of Primate Resources, which are used to support numerous research projects locally, national and internationally. This grant will also allow CPRC to continue supporting the Translational Science Initiative (TSI) under the Applied Research Component. A major strength of this TSI is conducting multidisciplinary collaborative studies to establish and validate NHP models for preclinical translational projects related to different human diseases. With continued NIH support, the CPRC will remain a significant national research resource and will be able to provide healthy Indian-origin rhesus monkeys of defined genetic and virological background to NIH-sponsored research programs.

Public Health Relevance

The CPRC continues to be a platform that supports numerous PHS-sponsored research projects locally, throughout USA and nationwide. The Center provides Indian-origin rhesus monkeys with defined genetic and virological background that serve as models for the development of effective treatments against human diseases. The CPRC will continue to be one of the largest nation-wide providers of high quality, genetically and virology characterized rhesus monkeys required for AIDS and for other biomedical research projects as well as a valuable research resource needed for behavioral and biomedical studies.

Project Start
1987-04-15
Project End
2023-11-30
Budget Start
2021-03-01
Budget End
2022-02-28
Support Year
34
Fiscal Year
2021
Total Cost
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Type
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
Patel, Biren A; Organ, Jason M; Jashashvili, Tea et al. (2018) Ontogeny of hallucal metatarsal rigidity and shape in the rhesus monkey (Macaca mulatta) and chimpanzee (Pan troglodytes). J Anat 232:39-53
Ramos-Benitez, Marcos J; Ruiz-Jimenez, Caleb; Rosado-Franco, Jose J et al. (2018) Fh15 Blocks the Lipopolysaccharide-Induced Cytokine Storm While Modulating Peritoneal Macrophage Migration and CD38 Expression within Spleen Macrophages in a Mouse Model of Septic Shock. mSphere 3:
Larson, Sam M; Ruiz-Lambides, Angelina; Platt, Michael L et al. (2018) Social network dynamics precede a mass eviction in group-living rhesus macaques. Anim Behav 136:185-193
Sariol, Carlos A; Nogueira, Mauricio L; Vasilakis, Nikos (2018) A Tale of Two Viruses: Does Heterologous Flavivirus Immunity Enhance Zika Disease? Trends Microbiol 26:186-190
Madlon-Kay, Seth; Montague, Michael J; Brent, Lauren J N et al. (2018) Weak effects of common genetic variation in oxytocin and vasopressin receptor genes on rhesus macaque social behavior. Am J Primatol 80:e22873
Kanthaswamy, Sreetharan; Oldt, Robert F; Ng, Jillian et al. (2018) Determination of major histocompatibility class I and class II genetic composition of the Caribbean Primate Center specific pathogen-free rhesus macaque (Macaca mulatta) colony based on massively parallel sequencing. J Med Primatol 47:379-387
Hardin, Anna M (2018) Genetic contributions to dental dimensions in brown-mantled tamarins (Saguinus fuscicollis) and rhesus macaques (Macaca mulatta). Am J Phys Anthropol :
Fernández, Peter J; Mongle, Carrie S; Leakey, Louise et al. (2018) Evolution and function of the hominin forefoot. Proc Natl Acad Sci U S A 115:8746-8751
Al-Attar, Ahmad; Alimova, Yelena; Kirakodu, Sreenatha et al. (2018) Activation of Notch-1 in oral epithelial cells by P. gingivalis triggers the expression of the antimicrobial protein PLA2-IIA. Mucosal Immunol 11:1047-1059
Ebersole, Jeffrey L; Novak, Michael John; Orraca, Luis et al. (2018) Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. Immunology 154:452-464

Showing the most recent 10 out of 89 publications