This proposal is designed to strengthen the existing consortium of laboratory animal diagnostic clinical services shared by Rockefeller University Cornell University Medical College, Sloan Kettering Institute and The Animal Medical Center. In addition, a major new focus of this proposal is to further the development of a more fundamental program of research related to laboratory animal medicine and pathology. The existing diagnostic facilities directly serve the research faculty at the four consortium institutions while providing diagnostic support services for five other metropolitan research facilities. Also, a national quality assurance program for diagnostic laboratories is sponsored through this resource. The existing laboratory personnel at The Rockefeller University include a board certified veterinary pathologist; a DVM board certified in laboratory animal medicine with a Ph.D in immunoserology and virology; an ASCP certified clinical microbiologist; a certified medical laboratory technician and a research assistant with a bachelor's degree in biology. Two full-time post-doctoral DVM fellows and more than 20 animal health technician or veterinary students train in this diagnostic laboratory each year. Over the past two years, the research program has been directed away from clinical case reports toward research involving more fundamental principles of animal disease. This proposal would enhance that movement by establishing a senior research oriented position of research scientist in addition to the clinical and service oriented staff presently employed. Research efforts will continue on improved antibody enhancement, new diagnostic techniques, sentinel and post-surgical rodent studies, in addition to the new program of cellular disease research. The consortium diagnostic unit would continue to support integrated programs in animal quarantine, vendor and colony surveillance, environmental monitoring and clinical case evaluations.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
5P40RR001180-17
Application #
2281459
Study Section
Animal Resources Review Committee (AR)
Project Start
1978-07-01
Project End
1995-06-30
Budget Start
1994-07-01
Budget End
1995-06-30
Support Year
17
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Rockefeller University
Department
Veterinary Sciences
Type
Other Domestic Higher Education
DUNS #
071037113
City
New York
State
NY
Country
United States
Zip Code
10065
Morse, S S (1997) The public health threat of emerging viral disease. J Nutr 127:951S-957S
Morse, S S (1994) Hantaviruses and the hantavirus outbreak in the United States. A case study in disease emergence. Ann N Y Acad Sci 740:199-207
Voss, R S; Heideman, P D; Mayer, V L et al. (1992) Husbandry, reproduction and postnatal development of the neotropical muroid rodent Zygodontomys brevicauda. Lab Anim 26:38-46
Okin, P M; Donnelly, T M; Parker, T S et al. (1992) High-frequency analysis of the signal-averaged ECG. Correlation with left ventricular mass in rabbits. J Electrocardiol 25:111-8
Morse, S S (1992) Evolving views of viral evolution: towards an evolutionary biology of viruses. Hist Philos Life Sci 14:215-48
Zaoutis, T E; Reinhard, G R; Cioffe, C J et al. (1991) Screening rabbit colonies for antibodies to Pasteurella multocida by an ELISA. Lab Anim Sci 41:419-22
Glennon, P J; Cockburn, T; Stark, D M (1991) Prevalence of feline immunodeficiency virus and feline leukemia virus infections in random-source cats. Lab Anim Sci 41:545-7
Morse, S S (1991) Emerging viruses: defining the rules for viral traffic. Perspect Biol Med 34:387-409
Morse, S S (1990) Comparative sensitivity of infectivity assay and mouse antibody production (MAP) test for detection of mouse thymic virus (MTLV). J Virol Methods 28:15-23
Morse, S S (1990) Critical factors in an enzyme immunoassay (ELISA) for antibodies to mouse thymic virus (MTLV). Lab Anim 24:313-20

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