Abstract

The specific aims of this project are: 1. To procure new potentially valuable neurological, immunological and endocrinological mutants of mice that occur spontaneously in the breeding colonies of the Jackson Laboratory; 2. To characterize the new mutations genetically with respect to mode of inheritance, allelism, and linkage relationship; 3. To characterize the new mutants phenotypically with respect to fertility, longevity, growth, viability, and behavior; 4. To study the anatomical, histopathological, and physiological abnormalities of selected new mutants; 5. To develop suitable strains for maintaining and studying new and established mouse mutations so as to keep the mutant and normal allele segregating on a uniform genetic background; 6. To preserve established mutants as frozen embryos to assure their continued availability; 7. To make mutants and mutant-bearing mice available to the scientific community.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
5P40RR001183-08
Application #
3103381
Study Section
Mammalian Genetics Study Section (MGN)
Project Start
1978-07-01
Project End
1988-06-30
Budget Start
1985-07-01
Budget End
1986-06-30
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code

  Publications

Davisson, Muriel T; Cook, Susan A; Akeson, Ellen C et al. (2015) Kidney adysplasia and variable hydronephrosis, a new mutation affecting the odd-skipped related 1 gene in the mouse, causes variable defects in kidney development and hydronephrosis. Am J Physiol Renal Physiol 308:F1335-42
Sakami, Sanae; Kolesnikov, Alexander V; Kefalov, Vladimir J et al. (2014) P23H opsin knock-in mice reveal a novel step in retinal rod disc morphogenesis. Hum Mol Genet 23:1723-41
Li, Qiaoli; Pratt, C Herbert; Dionne, Louise A et al. (2014) Spontaneous asj-2J mutant mouse as a model for generalized arterial calcification of infancy: a large deletion/insertion mutation in the Enpp1 gene. PLoS One 9:e113542
Korstanje, Ron; Caputo, Christina R; Doty, Rosalinda A et al. (2014) A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen ?3?4?5(IV) trimers. Kidney Int 85:1461-8
Potter, Gregory B; Santos, Marta; Davisson, Muriel T et al. (2013) Missense mutation in mouse GALC mimics human gene defect and offers new insights into Krabbe disease. Hum Mol Genet 22:3397-414
Nilsson, Ida A K; Lindfors, Charlotte; Schalling, Martin et al. (2013) Anorexia and hypothalamic degeneration. Vitam Horm 92:27-60
Schramm, R Dee; Li, Shuai; Harris, Belinda S et al. (2012) A novel mouse Dscam mutation inhibits localization and shedding of DSCAM. PLoS One 7:e52652
Davisson, Muriel T; Bergstrom, David E; Reinholdt, Laura G et al. (2012) Discovery Genetics - The History and Future of Spontaneous Mutation Research. Curr Protoc Mouse Biol 2:103-118
Flaherty, John P; Fairfield, Heather E; Spruce, Catrina A et al. (2011) Molecular characterization of an allelic series of mutations in the mouse Nox3 gene. Mamm Genome 22:156-69
Lindfors, Charlotte; Nilsson, Ida A K; Garcia-Roves, Pablo M et al. (2011) Hypothalamic mitochondrial dysfunction associated with anorexia in the anx/anx mouse. Proc Natl Acad Sci U S A 108:18108-13

Showing the most recent 10 out of 142 publications