During the past two years the Caribbean Primate Research Center (CPRC) Program has been significantly improved with both NIH and commonwealth support. The CPRC's research infrastructure and environment, collaborative research program, animal care program and facilities, scientific and technical staff, research training programs, computer system and administrative support have all been greatly strengthened and increased. The major objectives are for the CPRC to achieve its full potential as a biomedical research facility for investigations on spontaneous diseases and conditions of aging monkeys and to maintain its leadership role in sociobiological studies of free-ranging macaques. In order to attain these goals, the CPRC is requesting five years of continued support at a significantly increased level of funding.
The specific aims are to maintain the Center's three unique international research resources at Cayo Santiago, the Sabana Seca Field Station and CPRC Skeletal Collection and to provide funding assistance to the University of Puerto Rico so that the additional scientists necessary to compete effectively for research grants and contracts can be recruited, the intramural and collaborative research and training programs can be further strengthened, new technologies such as DNA fingerprinting can be applied to ongoing studies of diseases and behavior and AAALAC accreditation can be obtained. In addition to core support, funds are also requested for the CPRCs research program on behavioral biology, metabolic disorders (diabetes, obesity, hypertension), ophthalmologic pathology (macular degeneration), skeletal biology and pathology (arthritis and osteoporosis), aging and immunology. With the requested support the CPRC will improve its research effectiveness and can provide its staff, the University of Puerto Rico and the international scientific community with an unparalleled opportunity to investigate both the behavioral and biomedical facets of nonhuman primate biology.

Project Start
1987-04-15
Project End
1995-04-14
Budget Start
1990-04-20
Budget End
1991-04-14
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
University of Puerto Rico Med Sciences
Department
Type
Schools of Medicine
DUNS #
City
San Juan
State
PR
Country
United States
Zip Code
00936
Ebersole, Jeffrey L; Novak, Michael John; Orraca, Luis et al. (2018) Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. Immunology 154:452-464
Gonzalez, O A; Kirakodu, S; Novak, M J et al. (2018) Comparative analysis of microbial sensing molecules in mucosal tissues with aging. Immunobiology 223:279-287
Rosati, Alexandra G; Santos, Laurie R (2017) Tolerant Barbary macaques maintain juvenile levels of social attention in old age, but despotic rhesus macaques do not. Anim Behav 130:199-207
Kessler, Matthew J; Wang, Qian; Cerroni, Antonietta M et al. (2016) Long-term effects of castration on the skeleton of male rhesus monkeys (Macaca mulatta). Am J Primatol 78:152-66
Wang, Qian; Turnquist, Jean E; Kessler, Matthew J (2016) Free-ranging Cayo Santiago rhesus monkeys (Macaca mulatta): III. Dental eruption patterns and dental pathology. Am J Primatol 78:127-42
Widdig, Anja; Kessler, Matthew J; Bercovitch, Fred B et al. (2016) Genetic studies on the Cayo Santiago rhesus macaques: A review of 40 years of research. Am J Primatol 78:44-62
Ebersole, J L; Kirakodu, S; Novak, M J et al. (2016) Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa. Mol Oral Microbiol 31:18-32
Gonzalez, O A; Nagarajan, R; Novak, M J et al. (2016) Immune system transcriptome in gingival tissues of young nonhuman primates. J Periodontal Res 51:152-63
Kessler, Matthew J; Rawlins, Richard G (2016) A 75-year pictorial history of the Cayo Santiago rhesus monkey colony. Am J Primatol 78:6-43
Wang, Qian; Kessler, Matthew J; Kensler, Terry B et al. (2016) The mandibles of castrated male rhesus macaques (Macaca mulatta): The effects of orchidectomy on bone and teeth. Am J Phys Anthropol 159:31-51

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