Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
Project #
5P40RR012305-09
Application #
7153952
Study Section
National Center for Research Resources Initial Review Group (RIRG)
Project Start
2005-08-01
Project End
2006-07-31
Budget Start
2005-08-01
Budget End
2006-07-31
Support Year
9
Fiscal Year
2005
Total Cost
$593,229
Indirect Cost
Name
Case Western Reserve University
Department
Genetics
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Doerner, Stephanie K; Reis, Edimara S; Leung, Elaine S et al. (2016) High-Fat Diet-Induced Complement Activation Mediates Intestinal Inflammation and Neoplasia, Independent of Obesity. Mol Cancer Res 14:953-965
Sinasac, D S; Riordan, J D; Spiezio, S H et al. (2016) Genetic control of obesity, glucose homeostasis, dyslipidemia and fatty liver in a mouse model of diet-induced metabolic syndrome. Int J Obes (Lond) 40:346-55
Maywald, Rebecca L; Doerner, Stephanie K; Pastorelli, Luca et al. (2015) IL-33 activates tumor stroma to promote intestinal polyposis. Proc Natl Acad Sci U S A 112:E2487-96
Buchner, David A; Nadeau, Joseph H (2015) Contrasting genetic architectures in different mouse reference populations used for studying complex traits. Genome Res 25:775-91
Spiezio, Sabrina H; Amon, Lynn M; McMillen, Timothy S et al. (2014) Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice. Mamm Genome 25:549-63
Dazard, Jean-Eudes J; Sandlers, Yana; Doerner, Stephanie K et al. (2014) Metabolomics of ApcMin/+ mice genetically susceptible to intestinal cancer. BMC Syst Biol 8:72
Cannon, Matthew V; Buchner, David A; Hester, James et al. (2014) Maternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspring. PLoS One 9:e90335
Smith, Lauren M; Bigelow, Erin M R; Nolan, Bonnie T et al. (2014) Genetic perturbations that impair functional trait interactions lead to reduced bone strength and increased fragility in mice. Bone 67:130-8
Hursting, Stephen D; Digiovanni, John; Dannenberg, Andrew J et al. (2012) Obesity, energy balance, and cancer: new opportunities for prevention. Cancer Prev Res (Phila) 5:1260-72
Buchner, David A; Geisinger, Jon M; Glazebrook, Patricia A et al. (2012) The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity. Mamm Genome 23:431-42

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