The University of Oklahoma Health Sciences Center (OUHSC) has established a baboon research resource with the resource with the essential support of this P40 grant, two C06 construction grants and a R24 Specific Pathogen Free (SPF) grants that provide baboons for research investigators throughout the United States. Our mission is to provide immediate availability of high quality, behaviorally healthy baboons and to serve as a national resource for biomedical and behavioral research requiring baboons. The baboon colony has grown from 141 baboons at the outset of the P40 grant support to a colony of 506 baboons. Over the past five years we supplied 452 baboons to outside research investigators located at 27 institutions across the United States and 111 infant baboons were supplied to the OUHSC SPF program. Together with the Oklahoma State University Center for Veterinary Health Sciences and the Texas Tech University Health Sciences Center, we have produced 40 peer reviewed publications during the last five years. The publications are the result of the P40 support of resource based research. The published articles add to the knowledge and increase the utility of baboons as models for biomedical research. These combined efforts have resulted in an increase in the number of baboons available for and provided to research investigators along with increasing their attractiveness for several areas of investigation of biomedical research. ? ? We continue to experience an increase in research requests involving primates not only locally but ? nationwide. During the next funding period we propose to continue the development and expansion of the baboon breeding and research programs in order to increase our ability to meet the increased demand for baboons and to encourage the attractiveness of non-human primates as a research model. To meet this goal we will 1) continue to support the increasing demand for NIH funded biomedical and behavioral research programs that require baboons at the local, regional, and national level; 2) continue to support development of the OUHSC SPF colony; 3) more aggressively optimize cost recovery to work towards self-sufficiency; 4) hire a full-time PhD level behaviorist to work with the colony; and 5) support resource based research to improve emphasis on development of the baboon as a model. ? ? ?

National Institute of Health (NIH)
National Center for Research Resources (NCRR)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Material Resource Grants (P40)
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National Center for Research Resources Initial Review Group (RIRG)
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Harding, John D
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University of Oklahoma Health Sciences Center
Schools of Medicine
Oklahoma City
United States
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Zimmerman, Lindsey I; Papin, James F; Warfel, Jason et al. (2018) Histopathology of Bordetella pertussis in the Baboon Model. Infect Immun 86:
Zhang, Zhongqiang; Gao, Bingsi; Zhao, Chengjiang et al. (2017) The impact of serum incubation time on IgM/IgG binding to porcine aortic endothelial cells. Xenotransplantation 24:
Iwase, Hayato; Hara, Hidetaka; Ezzelarab, Mohamed et al. (2017) Immunological and physiological observations in baboons with life-supporting genetically engineered pig kidney grafts. Xenotransplantation 24:
Li, Tao; Lee, Whayoung; Hara, Hidetaka et al. (2017) An Investigation of Extracellular Histones in Pig-To-Baboon Organ Xenotransplantation. Transplantation 101:2330-2339
Warfel, Jason M; Zimmerman, Lindsey I; Merkel, Tod J (2016) Comparison of Three Whole-Cell Pertussis Vaccines in the Baboon Model of Pertussis. Clin Vaccine Immunol 23:47-54
Iwase, Hayato; Liu, Hong; Wijkstrom, Martin et al. (2015) Pig kidney graft survival in a baboon for 136 days: longest life-supporting organ graft survival to date. Xenotransplantation 22:302-9
Iwase, Hayato; Kobayashi, Takaaki (2015) Current status of pig kidney xenotransplantation. Int J Surg 23:229-233
Iwase, Hayato; Ekser, Burcin; Satyananda, Vikas et al. (2015) Pig-to-baboon heterotopic heart transplantation--exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens. Xenotransplantation 22:211-20
Liu, Hong; Iwase, Hayato; Wijkstrom, Martin et al. (2015) MYROIDES INFECTION IN A BABOON AFTER PROLONGED PIG KIDNEY GRAFT SURVIVAL. Transplant Direct 1:
Azimzadeh, Agnes M; Kelishadi, Sean S; Ezzelarab, Mohamed B et al. (2015) Early graft failure of GalTKO pig organs in baboons is reduced by expression of a human complement pathway-regulatory protein. Xenotransplantation 22:310-6

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